Clinical Chemistry Lecture Exam II

MLS 4410

The parent substance for all steroid hormones is:

Cholesterol

The urinary excretion product measured as an indicator of epinephrine production:

Vanillylmandelic acid

Gout is characterized by accumulation of what in the joints?

Uric acid

In creatinine clearance, 1.73 is used to:

Normalize clearance by making it independent of muscle mass

John Doe’s lab results are as followed. His chemistry profile is indicative of what?

BUN: 12 mg/dL

CREA: 1.5 mg/dL

Uric acid: 60 g/dL

Gout

Secretion of hormones by the anterior pituitary is controlled by circulating levels of hormones from the target gland and the:

Hypothalamus

Which of the folllowing is a tropic hormone?

FSH

ACTH secretion is inhibited by high levels of:

Cortisol

Which of the following is secreted by the posterior pituitary gland?

ADH

A 11-year old patient is found to have mildly elevated alkaline phosphatase. This is…

Normal for growing children

Which of the following is most affected by hemolysis?

Lactate dehydrogenase

Which of the following is most specific for acute pancreatitis?

Lipase

Following an MI, which of the following increases most?

AST

The greatest source of CK is:

Skeletal muscle

Unconjugated bilirubin in the bloodstream is bound to:

Albumin

The enzyme that conjugates bilirubin in the hepatocyte is:

UDP-glucuronic aminotransferase

Which stage of chronic kidney disease has been subdivided into two stages to reflect GFR and renal function?

III

A patient with GFR of 10mL/min/1.73m² would be considered in which stage of CKD?

V

Impetigo caused by GAS would likely lead to which of the following?

Acute glomerulonephritis

A specimen collected for the measurement of ammonia can be collected and processed in the same manner as a specimen collected for a serum creatinine measurement.

False

Which of the following is most at risk for an initial diagnosis of gout?

60-year old man

All of the following are true about serum creatinine except:

Decreased levels indicate CKD.

In clinical practice, GFR is routinely estimated by the determination of serum creatinine. If more exact data are needed, ___ is used.

Creatinine clearance

An increasse in cortisol levels is defined as:

Cushing’s

Hirtsuism is a clinical manifestation of:

Addison’s

The action of a ___ hormone is specific for another endocrine gland:

Tropic

Hypothalamic/pituitary disease is a ___ cause of Addison’s disease.

Secondary

Which of the following is an adrenal cortical hormone?

Aldosterone

Primary adrenal insufficiency requires demonstration of:

Impaired response to ACTH stimulation

Which of the following is the most sensitive liver enzyme for excessive alcohol consumption?

GGT

Enzyme reactions measured in a clinical setting are most commonly measured using:

Zero-order kinetics

Lipase is more specific than amylase for the diagnosis of what?

Acute pancreatitis