Unit 4 Integumentary System

What is the sequence of events leading from increased androgen levels to inflammatory acne?

stimulation of oil glands, the plugging of pores, and the activation of the immune system.

How does follicular obstructions contribute to acne formation?

by the combination of excess sebum and skin cell buildup.

How do brain injuries lead to increased capillary permeability?

inflammatory mediators are triggered and leads to increased capillary permeability.

How does fluid shift from the vascular space into tissues following a burn?

loss of collagen linking creates abnormal osmotic and hydrostatic gradients which causes this.

What is the mechanism by which burns lead to hypovolemic shock?

massive fluid shifts from the intravascular space to the interstitial space.

Why are full thickness burns less painful than superficial burns?

nerves and tissues are necrotic therefore there is no feeling/pain.

Why does cellulitis spread through deeper tissues rather than remaining localized?

it spreads deeper because of a bacterial infection (strep).

How does abscess formation result from the immune response?

it forms as a protective immune response where the body fights off an infection using white blood cells.

How does sustained pressure lead to tissue necrosis in pressure ulcers?

by compressing blood vessels, leading to ischemia and nutrient deprivation.

How does immune activation lead to increased keratinocyte turnover in psoriasis?

through a cytokine-mediated feedback loop.