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Calculate person years
Person time: Total amount of time subjects are enrolled in the trial
*just add up each person's time
Rate for survival analysis
Rate = Number of events/ person time
Describe a Kaplan-Meier plot
•Step down when events occur
plus = censored
Describe a log rank plot
H0= Survival probability is equal in both groups
HA: survival probability is different between the groups
CROSSING OVER means not statistically significant
Assumes censoring unrelated to prognosis
Determine when survival analysis is appropriate
•Used to compare time to events
→ Dependent variable is time it takes to have that event
→Must be binomial outcome (yes or no)
→Cannot use logistic regression
Survival function
Probability of being event free at time t
Hazard function
instantaneous probability of having event at time t
Interpret a hazard ratio
Relative risk difference at that specific moment in time assuming survived to that time
Note
Flashcard