Heart Failure & Cholesterol
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6 Terms
Sacubitril/Valstartan
block neprilysin and angiotensin II to angiotensin receptor conversion » more bradykinin and angiotensin II » increases vasodilation
Digoxin
block Na/IK ATP ase » less Ca removal, more Ca binding to troponin
increase vagal firing, PSNS
atorvastatin
high intensity statin, inhibit HMG CoA reductase » lower cholesterol by increasing LDL-R
increased liver enzymes, myopathy, T2 diabetes risk
alirocumab
inhibit PCSK9 » more LDL clearance
ezetimibe
block intestinal cholesterol absorption » more LDL clearance, lower absorption of dietary and biliary cholesterol
bempedoic acid
inhibit ATP citrate lyase » lowers cholesterol precursor in liver
