lab 3 Nerolin
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10 Terms
purpose of this lab
produce nerolin from 2-naphthol and ethyl iodide via williamson ether synthesis
williamson ether synthesis
sn2 reaction that produces an ether from an alcohol and alkyl halide
nucleophile in this experiment
hydroxide ion
substrate of this experiment
iodomethane
alkoxide ion
when a strong base removes the hydroxy proton so the negative charge can delocalize over the four atoms → makes nucleophile stronger
reaction
2-naphthol + ethyl iodide →KOH (solv)→ nerolin
which solvents promote these reactions
Polar Aprotic
why are alkoxides preferred in these reactions
better nucleophiles than neutral alcohols
whats important in this reaction
structure of the alkyl halide (1 or methyl) and the leaving group ability of the halogen is important in this reaction
purpose of KOH
it’s added to convert naphthol into a better nucleophile, deprotonates hydroxide to give alkoxide
