ne102 3/23 lecture - iPSCs, organoids, applications, genome mods
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9 Terms
organoid
structures that are made when group of iPSCs develop (w help of TRs) that can resemble a specific organ
from iPSCs to organoids
reprogramming skin cells (fibroblasts) into iPSCs → differentiated into dedicated set of cells by TRs; used to study diseasees + design therapies!
what helps differentiate specific cells in organoid development
transcription regulators
brain organoids
cells are organized in layers, resembling cellular organization in the brain
use of iPSCs to study..?
brain function/disease, senescence/DNA mods, human diseases via derived organoids
applications for the use of organoids
drug screening + cell replacement therapy
autologous cell therapy
from self to self, reprogram somatic cells → iPSCs → gene correction
allogenic cell therapy
from self to others, iPSCs go through genetic eng → universal donor iPSCs → gene correction
how can ts help parkinsons disease?
PD caused by selective neurodegeneration → cell replacement therapy could be promising; ex: allogenic treatment (bemdaneprocel cell therapy)
