307 Major adverse effects

Verapamil

• Bradycardia

• Constipation

• Heart block

• Hypotension

• Peripheral edema

Digoxin

• Nausea/vomiting

• Confusion

• Visual disturbances

• Cardiac arrhythmias

• Toxicity with hypokalemia/hypomagnesemia

• Anorexia

Nitroglycerin

• Headache

• Postural hypotension

• Reflex tachycardia

• Contact dermatitis (with patches)

• Tolerance development

Furosemide

• Electrolyte imbalances

• Dehydration

• Hypotension

• Ototoxicity

• Hyperuricemia

Heparin

• Bleeding

• Thrombocytopenia

• Osteoporosis (long-term)

• Local injection site reactions

• Elevated liver enzymes

Valsartan

• Hyperkalemia

• Hypotension

• Dizziness

• Renal dysfunction

• Cough

Hydralazine/Isosorbide Dinitrate

• Headache

• Hypotension

• Tachycardia

• Lupus-like syndrome

• Peripheral neuropathy

Metoprolol/Propranolol

• Fatigue

• Bradycardia

• Bronchospasm

• Depression

• Sexual dysfunction

• Cold extremities

Ivabradine

• Atrial fibrillation

• Bradycardia

• Visual disturbances

• Conduction disturbances

• QT prolongation

Hydrochlorothiazide

• Hypokalemia

• Hyperglycemia

• Hyperlipidemia

• Hyperuricemia

• Photosensitivity

Enalapril

• Persistent dry cough

• Angioedema

• Hyperkalemia

• First-dose hypotension

• Renal impairment

Valsartan/Sacubitril

• Hypotension

• Hyperkalemia

• Angioedema

• Renal failure

• Fetal toxicity (black box warning)