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Genotype
Genetic makeup of an individual
Phenotype
Outward expression of genes
High Risk Genetics
Age >35, family history, teratogens, previous anomalies
Common Teratogens
Alcohol, ACE inhibitors, cocaine, warfarin, CMV, rubella, toxoplasmosis, zika
Organogenesis
Completed by week 8; highest teratogenic risk
Fetal Heartbeat Detectable
6 weeks ultrasound, 10-12 weeks Doppler
Carrier Testing
Identifies risk of inherited genetic disorders
Preimplantation Testing
Done before embryo transfer during IVF
Placenta Function
Gas exchange, nutrients, hormones progesterone estrogen hCG hPL
Amniotic Fluid
Protects fetus, maintains temperature, cushions, allows movement
Umbilical Cord
1 vein oxygenated, 2 arteries deoxygenated, Whartons jelly prevents compression
Whartons Jelly
Protective substance around umbilical vessels
Umbilical Arteries
Carry deoxygenated blood away from fetus
Umbilical Vein
Carries oxygenated blood to fetus
Ductus Venosus
Shunts blood from umbilical vein to inferior vena cava
Foramen Ovale
Shunts blood between fetal atria, closes after birth
Ductus Arteriosus
Shunts blood from pulmonary artery to aorta, closes after birth
Presumptive Signs
Subjective: amenorrhea, fatigue, nausea, quickening
Probable Signs
Objective: positive hCG, Chadwicks sign, Goodells sign
Positive Signs
Fetal heart tones, ultrasound, palpated fetal movement
Naegeles Rule
EDD = LMP +7 days -3 months +1 year
First Trimester
Weeks 0-13: organogenesis, fatigue, nausea, breast tenderness
Second Trimester
Weeks 14-27: quickening, anatomy scan, stable mood
Third Trimester
Weeks 28-40: weight gain, SOB, edema, Braxton Hicks
Supine Hypotension
Caused by vena cava compression; reposition left lateral
Kick Counts
Begin 28 weeks; expect 10 movements in 2 hours
Key Prenatal Labs
CBC, Rh, HIV, RPR, Hep B, Rubella, glucose, GBS
Gestational Diabetes Screen
24-28 weeks; 1-hour glucose challenge test
Group B Strep Testing
35-37 weeks; IV penicillin if positive
Quad Screen
15-20 weeks; tests for genetic anomalies
GBS Positive Care
Give IV penicillin during labor
Estimated Fetal Weight
Measured by fundal height; weeks roughly equals cm between 18-30
EDD Calculation
First day of LMP +7 days -3 months +1 year
Danger Signs First Trimester
Bleeding, severe cramping, hyperemesis, fever
Danger Signs Second Trimester
No fetal movement, bleeding, pelvic pain
Danger Signs Third Trimester
Severe headache, vision changes, RUQ pain, bleeding
Preeclampsia Signs
BP >140/90, proteinuria, headache, visual changes, RUQ pain
Severe Preeclampsia
BP >160/110, oliguria, hyperreflexia, headache
Eclampsia
Preeclampsia + seizures
HELLP Syndrome
Hemolysis, Elevated Liver Enzymes, Low Platelets
Placenta Previa
Painless bright bleeding, soft uterus, avoid vaginal exams
Placental Abruption
Painful dark bleeding, rigid uterus, abnormal FHR
Hyperemesis Gravidarum
Severe vomiting, dehydration, weight loss, ketonuria
Hydatidiform Mole
Abnormal growth of placental tissue, positive hCG, no heartbeat
Rh Incompatibility
Rh- mom with Rh+ baby; give RhoGAM at 28 weeks and postpartum if needed
Magnesium Sulfate
Prevents seizures in preeclampsia; monitor for toxicity
Magnesium Toxicity Signs
Low reflexes, RR<12, UOP<30mL/hr; antidote calcium gluconate
Calcium Gluconate
Reverses magnesium toxicity
Oxytocin Use
Induces labor; stop if tachysystole or late decels
Betamethasone
Given 24-34 weeks to promote fetal lung maturity
Terbutaline
Tocolytic; delays preterm labor; monitor maternal tachycardia
RhoGAM
Prevents maternal sensitization in Rh- mothers
IV Penicillin
Given to GBS-positive clients during labor
Folic Acid Supplement
Prevents neural tube defects; start preconception
Late Decelerations
Placental insufficiency; reposition, oxygen, fluids, notify provider
Variable Decelerations
Cord compression; reposition client
Early Decelerations
Head compression; normal finding
Normal FHR
110-160 bpm
Minimal Variability
Can indicate hypoxia or sleep; monitor closely
Absent Variability
Non-reassuring, possible fetal compromise
Accelerations
Increase in FHR greater than or equal to 15 bpm for greater than or equal to 15 sec; reassuring
Psychosocial First Trimester
Ambivalence, anxiety, mixed emotions
Psychosocial Second Trimester
Acceptance, bonding, better mood
Psychosocial Third Trimester
Impatience, labor anxiety, body image issues
Cultural Competence
Knowing patient beliefs and customs
Cultural Humility
Respecting preferences; adapting care
Trauma Informed Care
Ask permission, explain procedures, give choices