Plasticity studies

robinson and kolb

repeated cocaine increases spine density in accumbens neurons

badiani et al 19

more robust psychomotor sensitisation to cocaine in novel context compared to home

li et al 2004

novel contexts result in robust psychomotor sensitisation and increased spine density

Bell and Kalivas 2000

cocaine-induced glutamate release is enhanced in novel context when prior cocaine happened in novel (sensitisation of glutamate release)

robinson et al 2001

cocaine seld administration reorganises patterns of connectivity in the accumbens

crombag et al 2005

drug self administration training alters patterns of connectivity while sucrose self administration doesnt

Bondreau and wolf 2005

AMPAR surface expression is increased 14 days after amphetamine, but not 1 day after

kauer and malenka 2007

higher AMPAR:NMDAR ratio makes synapses stronger

kourrich et al 2007

repeated cocaine increases synaptic strength

britt et al 2012

AMPAR:NMDAR ratios increased in hippocampal-NAcc synapses after cocaine

ungless et al 2001

both single and multiple cocaine injections increase synaptic strength at VTA DA neurons, but transiently

Chen et al 2008

cocaine self administration persistently increases VTA synaptic strength

conrad et al 2008

long term cocaine withdrawal after self-administration associated with increased cocaine seeking and AMPAR subunit change

CP-AMPARs

calcuim permeable AMPARs. blocking of these with NASPM disrupts cocaine seeking

Koya et al 2009

selective inactivation of behaviourally activated neurons using Daun02 in c-fos-lacZ rats