PHRD 514: Compounding Final

Methocarbamol capsule route

Oral

Methocarbamol capsule use

Eliminate unpleasant odor/taste

Boric acid capsule route

Vaginal

Boric acid capsule use

Direct delivery of active ingredient to target area for treatment of infection

APAP capsule route

Rectal

APAP capsule use

Modified release of active ingredient for quicker antipyretic action

Largest capsule size

000

Smallest capsule size

5

Hand-punch

Method used to determine an average capsule weight before encapsulating powder mix

Trituration technique

Apply sufficient force and consistent number of presses

Gelatin

Primary material used to make the shells of most capsules

Primary goal of geometric dilution

To achieve a homogenous mixture of ingredients

Methylcellulose

Hydroxypropyl methylcellulose (Methocel E4M)

Excipients commonly used in the compounding of capsules for proper drug release

Ointment

Viscous oleaginous or polymeric semisolid dosage form (primarily drug + hydrocarbon base)

Cream

A dosage form comprising a viscous semisolid emulsion (primarily o/w but can be any)

Topical

Ointments, creams, gels to deliver API to the SKIN

Transdermal

Ointments, creams, gels to deliver API to the CIRCULATION

Normal to oily

Ointment

Paste

Gel

Normal to dry

Lotion

Dry

Cream

Ointment

Hairy

Lotion

Gel

Spray

Intertriginous areas (where skin tends to rub together often)

Cream

Lotion

Wet, vesicular, weeping lesions

Cream

Lotion

Gel

Dry, thickened, scaly lesions

Ointment

Paste

Hydrocarbon (Oleaginous)

White petrolatum

White ointment

Vaseline

Anhydrous brands

Lanolin

Aquaphor

Water-in-oil emulsion brands

Cold Cream

Eucerin

Nivea

Oil-in-water emulsion (hydrophilic ointment)

Dermabase

Velvachol

Mineral oil used as levigating agent

(Bases in levigation)

Hydrocarbon

Anhydrous absorption

Water-in-oil emulsion

Glycerin as a levigating agent

Oil-in-water emulsion

Water-soluble base

Levigation

Process of reducing particle size of a solid by triturating it with a small amount of liquid or melted base in which the solid is not soluble

Bases in order from highest to lowest occlusiveness

Most Occlusive Hydrocarbon

W/O absorption

O/W water-removable

Least Occlusive Water soluble

Occlusive definition

When a topical forms a barrier on the skin, preventing moisture loss

Suppository/Insert

Solid dosage form used to administer medicine through the rectum or vagina or urethra

Local suppository uses

Hemorrhoids, itching, and infections

Systemic suppository uses

Antinausea, analgesic, hormones

PEG-Polyethylene Glycol

Most popular choice for suppository base

Fatty bases

Preferred for rectal suppositories

PEG bases

Preferred for vaginal and urethral inserts

Rectal suppository common weight adults

2 g

Rectal suppository common weight pediatric

1 g

Food and Drug and Cosmetic Act of 1938

Laws for pharmacy compounding; outsourcing facilities providing sterile medications to patients without a patient-specific prescription

USP 795

Compounding quality nonsterile preparations

USP 797

Compounding sterile preparations

USP 800

Safe handling of hazardous drugs

USP 825

Standards for radiopharmaceuticals

USP

United States Pharmacopeia

Cleaning agent

Removal of substances from surfaces

Disinfectant agent

Used on inanimate surfaces and objects to destroy fungi, viruses, and bacteria

Sporicidal agent

Destroys bacterial and fungal spores, is expected to kill all vegetative microorganisms

What direction does cleaning need to be performed in

Clean to dirty

Order of cleaning laminar flow hood

Top/ceiling (left to right, back to front)

Rods/hangers (if present)

Sides x2 of inside of hood (one side at a time, top to bottom, back to front)

Counter (left to right, back to front)

ISO

International Organization for Standardization

Buffer room ISO Class requirement

Class 7

CSP Room ISO Class requirement

Class 5 or better

NIOSH

National Institute for Occupational Safety and Health

PEG base

Longest liquefaction time

Fusion

Compounding method requiring mold calibration or density calculations for accurate dosing

Levigating agent used to compound Nifedipine 0.2% rectal ointment in white petrolatum

Mineral oil

Auxillary warning for cream/topical

External use only

When compounding, items should be at least ____ inches from the front of the hood

6

After wiping the top of the vial with 70% IPA, how long should you wait to allow it to dry?

30 seconds

How long should you wash your hands and forearms prior to putting on gloves?

30 seconds

Correct order for donning PPE

Shoe covers

Hair cover

Face mask

Gown

Gloves

Which drug/strength capsule did we compound

Acetaminophen 100 mg capsules

PCAB

Organization that gives non-sterile/sterile compounding education accreditation

Water-removable base definition

Base that is cream-like, O/W emulsion, and had hydrocarbons

Insoluble in water

Hydrocarbon

Anhydrous absorption

Water-in-oil emulsion

Oil-in-water

Non-water washable

Hydrocarbon

Anhydrous

Water-in-oil

Anhydrous

Hydrocarbon

Anhydrous

Will not absorb water

Hydrocarbon

Emollient

(Characteristic of these)

Hydrocarbon

Anhydrous

Water-in-oil

Occlusive

Hydrocarbon

Anhydrous

Water-in-oil

Greasy

(Characteristic of these)

Hydrocarbon

Anhydrous

Water-in-oil

Can absorb water

Anhydrous

Water-in-oil

Oil-in-water

Water-soluble

Contains water

Water-in-oil

Oil-in-water

Water-soluble

Non-Occlusive

Oil-in-water

Water-soluble

Non-greasy

Oil-in-water

Water-soluble

Lipid free

Water-soluble

Emollient definition

Softening or soothing of the skin

Capsule BUD

180 days (or expiration of earliest expiring element)

Topical BUD

30 days

Injection

Liquid preparations that are drug substances or solutions

For injection

Dry solids, that upon addition of suitable vehicles, yield solutions conforming in all respects to the requirements for injections

Injectable emulsion

Liquid preparations of drug substances dissolved or dispersed in a suitable emulsion medium

Injectable suspension

Liquid preparations of solids suspended in a suitable liquid medium

For injectable suspension

Dry solids that, upon addition of suitable vehicles, yield preparations conforming in all respects to the requirements of injectable suspensions

USP 71

Sterility tests

USP 85

Bacterial endotoxin tests

USP 788

Particular matter in injections

USP 1075

Good compounding practices

USP 1116

Microbiological evaluation of cleanrooms and other controlled environments

USP 1191

Stability considerations

USP 823

Compounding radiopharmaceuticals

USP 1-999

Enforceable

USP 1000-1999

Not enforceable

Ante room ISO Class Requirement

Class 7

Buffer room ISO Class Requirement

Class 8

LAFW (Laminar Airflow Workbench) ISO class requirement

Class 5