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transcription
the process of copying genetic instructions from DNA to RNA
involves RNA polymerase
RNA polymerase
binds to the DNA and assembles the RNA
translation
converts the language of nucleotides into the language of amino acids; triplet code on the mRNA is converted to the language of amino acids
involves mRNA, tRNA, and ribosomes
occurs in three steps: initiation , elongation, and termination
messenger RNA
carries the genetic code from the nucleus to the cytoplasm
transfer RNA
binds free amino acids in the cytosol and delivers them to the ribosome to be added to a growing protein chain
glands
one or more cells that make and secrete a particular product; derived from epithelium
substances are secreted into ducts, onto surfaces, or into the blood
endocrine glands
secrete their product into the interstitial fluid and from there into the bloodstream; ductless
exocrine glands
secrete their products into ducts that empty onto a surface or into a lumen; ducted
cutaneous membrane
largest membrane of the body; keratinized stratified squamous epithelium with a dense irregular connective tissue layer
dry membrane - exposed to the air; skin
serous membrane
lines closed body cavities; simple squamous epithelium on a layer of areolar connective tissue
double layers with a thin layer of fluid in between
mucous membrane
lines body cavities that open to the outside; epithelium on a layer of areolar connective tissue and sometimes a layer of smooth muscle
wet membrane - surface remains moist; digestive, urinary, and reproductive tracts
synovial membrane
line synovial joints; no epithelial layer, just connective tissue
lubricates the joint, provides nutrients for cartilage and removes waste
stratum basale
most deep layer of the epidermis; a single layer of cuboidal to low columnar keratinocytes resting on the basement membrane; stem cells, melanocytes, and tactile cells
stratum spinosum
thickest stratum of the epidermis; several layers of keratinoctyes; deepest cells continue dividing, but as they’re pushed farther upward, they cease; dendritic cells
stratum granulosum
layer of the epidermis; three to five layers of flat keratinocytes; more in thick skin than in thin skin; dendritic cells
stratum lucidium
layer of the epidermis; thin zone of densely packed keratinocytes; only seen in thick skin
stratum corneum
most superficial layer of the epidermis; durable surface layer; consists of up to 30 layers of dead keratinized cells
papillary layer
layer of the dermis; thin zone of areolar tissue in and near the dermal papillae
reticular layer
deepest and thickest layer of the dermis; consists of dense irregular connective tissue
epidermis
a keratinized stratified squamous epithelium; five cell types and four to five layers
dendritic cells
immune cells that originate in the bone marrow but migrate; found in the stratum spinosum and stratum granulosum
tactile cells
receptors of touch; stratum basale
melanocytes
synthesize varieties of melanin; found in the stratum basale
stem cells
undifferentiated cells that divide and give rise to the keratinocytes; found in the stratum basale
keratinocytes
great majority of epidermal cells; synthesize keratin
dermis
connective tissue; two layers
sebaceous glands
produce an oily secretion called sebum; usually open into a hair follicle or directly onto the skin surface
ceruminous glands
modified apocrine glands found only in the external ear canal; yellow, waxy secretion combines with sedum and dead epidermal cells to form cerumen; coiled, simple tubular glands with ducts leading to hair follicles or the skin surface of the ear canal
apocrine sweat glands
scent glands that respond especially to stress and sexual stimulation; large lumen and ducts lead into nearby hair follicles
eccrine sweat glands
cool the body; simple tubular gland with a twisted coil in the dermis or hypodermis, and a coiling duct leading to a sweat pore on the skin surface
bone tissue
a connective tissue in which the matrix is hardened by the deposition of calcium phosphate and other minerals
function: support, protect, movement, RBC production, fat storage, mineral homeostasis
compact bone
outer shell of dense white osseous tissue; encloses the medullary cavity
spongy bone
loosely organized form of osseous tissue; at the ends of the bone
osteogenic cells
stem cells that develop from embryonic mesenchyme and then give rise to most other bone cell types
osteoblasts
bone forming cells that synthesize the organic matter of the bone and then promote its mineralization
osteocytes
former osteoblasts that have become embedded in the matrix they deposited
osteoclasts
bone dissolving cells on the bone surfaces
intramembranous ossification
produces the flat bones of the skull, most of the clavicle, and part of the mandible
endochondral ossification
development of a bone from a preexisting model composed of hyaline cartilage
bone elongation and widening
elongation: the epiphyseal plate consists of typical hyaline cartilage in the middle, with a transitional zone on each side where cartilage is being replaced
widening: appositional growth (deposition of new tissue at the surface)
bone remodeling
collaborative action of osteoblasts and osteoclasts that removes the matrix and gets rid of unnecessary mass (done by osteoclasts) and deposits new bone tissue and thickens it (done by osteoblasts)
calcitonin (calcium homeostasis)
secreted when the blood calcium concentration rises too high, and it lowers the concentration by osteoclast inhibition and osteoblast stimulation
parathyroid hormone (calcium homeostasis)
secreted when the blood calcium concentration is low, and it raises the calcium level by osteoclast stimulation, osteoblast inhibition, promoting urinary phosphate excretion, and inhibiting urinary calcium excretion
articulation
any point where two bones meet
joint functionality
synarthrosis, amphiarthrosis, or diarthrosis
joint structure
fibrous, cartilaginous, or synovial
fibrous joint - synarthrosis
a point at which adjacent bones are bound by collagen fibers that emerge fom one bone, cross the space between them, and penetrate into the other; three kinds - sutures, gomphoses, and syndesmoses
sutures
fibrous joint; immobile or slightly mobile; closely bind the bones of the skull to each other
gomphoses
fibrous joint; the attachment of a tooth to its socket
syndesmoses
fibrous joint; binds two bones by relatively long collagenous fibers
cartilaginous joint - amphiarthrosis
a point where two bones are linked by cartilage; two kinds - synchondroses and symphyses
synchondroses
cartilaginous joint; a joint in which the bones are joined by hyaline cartilage
sympheses
cartilaginous joint; a joint in which the bones are joined by fibrocartilage
synovial joints - diarthrosis
a point where two bones are separated by a narrow, encapsulated space filled with lubricating synovial fluid; relatively mobile joints; have accessory structures; six kinds - hinge, plane, condyloid, ball and socket, pivot, and saddle
tendons
a strip or sheet of tough collagenous connective tissue that attaches a muscle to a bone
ligament
a strip or sheet of tough collagenous connective tissue that attaches one bone to another
angular movements
movements that change the angle between two bones/structures, or between a bone and a midline
ex: flexion, extension, lateral flexion, abduction, adduction, circumduction
rotation movements
movements where a bone/structure rotates around its long axis or around a fixed
ex: rotation, circumduction, supination, pronation
gliding movements
movements where a bone/structure slides in the same plane
flexion
a movement that decreases a joint angle
extension
a movement that straightens a joint
hyperextension
a movement that extends a joint beyond the zero position
abduction
the movement of a body part away from the midline of the body
adduction
the movement of a body part back toward the midline
elevation
a movement that raises a body part vertically
depression
a movement that lowers a body part vertically
protraction
the anterior movement of a body part
retraction
the posterior movement of a body part
circumduction
a movement where one end of the appendage remains relatively stationary and the other end is moved in a circle
rotation
a movement in which a bone spins on its longitudinal axis
supination
a movement that turns the palm to face anteriorly or upward
pronation
a movement that turns the palm to face posteriorly or downward