PMLS 1 - Inventions and Innovations in the field of Medical Laboratory

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Father of Microbiology, Microscope

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1

Father of Microbiology, Microscope

Antonie van Leeuwenhoek

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2

Vaccination to establish immunity to small pox

Edward Jenner

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3

identified organs by their types of tissue

Marie Francois Xavier Bichat

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4

produced disease in worms by injection of organic material

Agostino Bassi

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5

produced immunity to rabies

Louis Pasteur

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6

demonstrated that surgical infections are caused by airborne organisms

Joseph Lister

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7

Presented the first pictures of bacilli (anthrax) and later tubercle bacilli

Robert Koch

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8

Described phagocytes in blood and their role in fighting infection (called phagocytosis)

Elie Metchnikoff

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9

Distinguished blood groups through the development of the ABO blood group system

Karl Landsteiner

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10

Discovered microorganisms whose range lies between bacteria and viruses called “rickettsiae”

Howard Ricketts

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11

Hepatitis B Vaccine

Baruch Samuel Blumberg

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12

Polymerase Chain Reaction

Kary Mulis

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13

Used microscope to document the existence of cells

Robert Hooke

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14

introduced a method of obtaining specimens for microscopic study

John Hill

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15

studied the great cholera outbreak in London

John Snow

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16

Developed methods of drying and fixing blood smears using heat

Discovered mast cells and classified white blood cells according to its granulation

Paul Ehrlich

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17

Penicillin (paramount in initiating the antibiotic era)

Alexander Fleming

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18

Developed an achromatic microscope and introduced dark-field microscopy

Joseph Jackson Lister

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19

Prepared the first synthetic dye

William Perkin

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20

Developed the first visual colorimeter based on Beer’s Law

Jules Duboscq

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21

Invented the nephelometer (an instrument for measuring the size and concentration of particles suspended in a liquid or gas, especially by means of the light they scatter)

Theodore Richards

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22

Discovered the reciprocal relationship between pH and oxygen content of hemoglobin (Bohr effect)

Christian Bohr

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23

Invented the fluorescence microscope

Oskar Heimstadlt

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24

Developed the colorimeter-nephelometer

Philip Adolf Kober

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25

developed the mass spectrograph

Francis William Aston

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26

published the first edition of diagnosis by laboratory methods

Arthur Sanford & James Todd

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27

developed moving boundary electrophoresis of proteins

Arne Tiselius

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28

determined the molecular weight of hemoglobin by ultracentrigufation

Theodore Svedberg

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29

introduced the use of light colorimetry

Otto Folin

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30

introduces Westgard control rules into clinical laboratory quality control

James Westgard

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31

Pap smear

George Nicholas Papanicolaou

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