Warren Antimicrobial PD

Which antiobiotic classes have concetration dependent killing?

Aminoglycosides
Quinolones
Metronidazole
Daptomycin

Which antiobiotic classes have time dependent killing?

B lactams
Glycopeptides
Macrolides
Rifampin
Tetracycline
Glycylcyclines
Oxazolidinones

Which antiobiotic classes have post antibtioc effects against Gram +

B lactams
GLycopeptides
Macrolides
Quinolones
Aminoglycosides
Rifampin
Tetracycline
Oxazolidinones

Which antiobiotic classes have post antibtioc effects against Gram -

Aminoglycosides
Quinolines
Carbapenems
RIfampin

What Antitibiotics have Cmax/MIC pharamcodynamic parameters

Aminoglycosides
Fluoroquinolones

What Antitittybiotics have AUC/MIC pharamcodynamic parameters

Fluoroquinolones
Macrolides
Tetracyclines
Clindaymycin

What Antitibiotics have Time>MIC pharamcodynamic parameters

B lactams
Linezolid
Tetracyclines
Macroldies
Clindamycin

Do high concentrations of B lactams enhance killing?

No, bc they exhibit time dependent killing
The focus is on maintaining drug levels above the MIC for as long as possible during the dosing interval

Prolonged infusion of beta-lactams

dosing strategy designed to maximize time-dependent killing and improve bacterial eradication. Instead of administering the drug as a short bolus (over 30 minutes), beta-lactams are infused over an extended period (2-4 hours) or even as a continuous infusion.

What is the rationale for single dose aminoglycosides

Higher peak concentrations should increase efficacy
Signif PAE allows for longer dosing intervals
Lower trough concentrations should improve safety
Longer dosing intervals may decrease resistance

What drives toxicity for aminoglycosides?

The trough level- Similar AUC exposure can lead to different % probability of toxicity

Vacno PD

AUC/MIC associated with efficacy

What is most important for vanco toxicity

AUC

T/F Higher vanco exposures do not improve tx success and increase risk of AKI

True