Campylobacter and Bordetella

What can cause bordetella in dogs?

Multifactorial: - stress -bordetella bronchi - K9 pneumonias

What is Bordetella?

An oppurtunistic upper resp infection - Aerobic

What is the pathogenesis of Bordetella

Aerosol transmission - biphasic virulent at higher temperature (37 degrees). Targets ciliated resp epithelium.

What does the tracheal cytotoxin of bordetella spp. do?

Paralysis of cilia and tracheobronchi al clearance

What does dermonecrotoxic toxin of bordetella spp. do?

induces dermal necrosis- turbinate atrophy

What does the osteotoxin of bordetella do?

KIlls osteoblasts

What will bordetella bronchioceptica affect?

Pigs - atrophic rhinitis.

Dogs- K9 infectious tracheobronhitis

What does Bordetella parapertussis affect?

Lambs - pneumonia

What are the clincal manifestations of bordetella bronchiseptica in dogs?

Coughing, retching, mild serous oculonasal discharge

-Respiratory in young animals

- can lead to fatal bronchopneumonia

What co-infection leads to atrophic rhinitis in swine?

Pasteurella multiocida and Bordetella Bronchiseptica

What are clinical manifestation of Bordetella avium?

Beak breathing, Sneezing, flattened trachea

What secondary infections can Bordetella avian lead to?

E. coli

What are ways to dx Bordetella in dogs?

History- boarding?

Culture

PCR: multi-panel (trachea fluid, sinus exudate)

What are treatments and prevention for Bordetella?

Isolation

Doxy and clavamox - ineffective for turkeys. Vax- modified live

Hygienic- Chlorination.

What will campylobacter fetus veneralis infect?

Bovine repro tracts - infertility and abortions.

What will campylobacter fetus fetus  infect?

Ruminant GI tract causing abortion

What will Campylobacter jejuni infect?

GI (puppies and kids) - enteritis (diarrhea) sometimes abortions

Venerial dz (Campylobacter) is more common in what states?

Western

Campylobacter jejuni is ___ and must be ___?

Zoonotic/ food bourne illness - Reported

What are the 2 most important virulence factors of Campylobacter and what do they do?

Microcapsule lattice - reduces complement and Phag

S layer - 8 variants for immune evasion 

What will cause bovine genital campylobacteriosis?

C. veneralis - temporary infertility, abortion.

Who are often asymptomatic carrier for C. veneralis?

Bulls

What are the 5 main causes of cattle infertility?

Brucella

Trichomonas

Leptospira

Salmonella

C. venerealis

When can C. venerealis cause permanent infertility?

If it migrates to oviducts from uterus

What organism will cause Ovine genital campylobacterosis?

C. fetus - Abortion in ewes - Necrotic placentitis

What organism will cause Canine intestinal campylobacteriosis?

C. jejuni

Most cases of C. jejuni are ___?

Subclinical

How does C. jejuni manifest in birds?

Avian vibrionic heptatitis -Necrotic liver, - decreased production -ZOONOTIC - food born

What is the standard dx for campylobacter?

PCR - low # of organisms difficult to culture sometimes - can get vaginal flush to do testingH

How is C. fetus treated?

Theraputic vax

Chlortetracyclines

How is C. veneralis treated?

Dihydrostreptomycin

pre/post breeding vax

How is C. jejuni treated?

ABX RESISTANT Dihydrostreptomycin - fluids and abx - puppies

What bacteria is in the Campylobacteria class that is zoonotic and can cause ulcers in humans?

Heliobacter