Organic Chemistry II Chapter 23: Nucleophilic Addition Elimination Reactions 2: Reagents that are weakly or non nucleophilic

Alcoholysis

a reaction in which an alcohol reactant is responsible for breaking bonds, used to convert a carboxylic acid derative into an ester

Hydrolysis

Type of reaction in which water is a reactant that facillitates the breaking of bonds, water is generally a nucleophile in these reactions

Aminolysis

A reaction in which an amine reactant is responsible for breaking bonds, used to convert carboxylic acid derative into an amide

Thinoyl chloride

compound SOCl2, used as a reagent to convert alcohols to alkyl chlorides and carboxylic acids to carboxylic acid chlorides

Hell-volhard-Zelinsky (HVZ) reaction:

A reaction in which the alpha carbon of carboxylic acid is brominated to produce an alpha bromic acid

Sulfonyl chloride

one of a class of compounds with general formula R-SO2Cl

Sulfonate Ester

A functional group with bonding arrangement R’O-SO2R. Sulfonate esters, typically possess very good leaving groups for nucleophilic substitution and elimination reactants

Fischer Esterification Reaction

An acid catalyzed reaction between an alcohol and carboxylic acid produces an ester

Bayer Villiger Oxidation

A reaction in which a peroxy acid converts a ketone or an aldehyde into an ester or a carboxylic acid.

Migratory Aptitude

tendency of a bond between a H or alkyl group and a carbonyl.

B Keto Ester

A species in which the B carbon of an ester is part of a carbonyl group that is characteristic of a ketone

Claisen Condensation Reaction

A reaction in which an enolate anion undergoes nucleophilic addition elimination with an ester, producing a B Keto ester

Crossed Claisen Condensation Reaction

A specific type of Claisen condensation reaction in which carbonyl containing reactants that join together are different

Active methylene compound

CH2 group with two adjacent C=O groups can be converted into a highly nucleophilic enolate anion relatively easily

B Keto Acid

a species in which the B carbon of a carboxylic acid is part of a carbonyl group that is characteristic of a ketone or aldehyde

Decarboxylation

A reaction that removes a carboxyl group from a molecule

Acetoacetic ester synthesis

A synthesis scheme that converts acetoacetic ester into an alkyl or dialkyl substituted acetone

Malonic ester synthesis

A synthesis scheme converts malonic ester into an alkyl or dialkyl substituted aceitc acid