Adrenergic Antagonists and Cholinergic Agonist Drugs

Prazosin

a1 Blocker, Vasodilator

Doxazosin

a1, not used today due to other issues

Tamulosin (Flomax)

a1, Benign Prostate Hypoplasia

a1 blocker Adverse Effects

Orthostatic Hypotension due to decreased blood pressure, Floppy iris syndrome

a2 agonists are -lytic?

Sympatholytic

-lol suffix means what?

Beta blocker

Propranolol

Non-selective Beta blocker, undesired effects (Vasoconstriction, bronchoconstriction). Hyperthyroidism and Anxiety

Careful mixing Propranolol with what? causes what?

Epinephrine, Cardiac arrest

Metaprolol

B1 Selective, minimal B2. Prolong survival after ACS

Labetalol and Carvedilol

Non-selective B, also a1 minorly. High BP

Carvedilol Uses and results

Hypertension, decreases mortality for heart failure

Beta Blockers Adverse Effects

Bradycardia, Fatigue, Block Vasoconstriction, bronchospasms, increase plasma glucose

M Evens are what G type?

GI

M odds are what G type?

GQ

Bethanechol, Methacholine, Pilocarpine have what type of effect?

Parasympathomimetic

Methacholine use

Airway hyper reactivity, lung function test

Pilocarpine use and Mechanism type

Dry Mouth (Xerostomia), Glaucoma, Direct

Do direct acting cholinergic agents and anticholinesterases have the same effect?

Yes

Neostigimine Mechanism type, and treatment use

REVERSIBLE, ACh Esterase inhibitor for Myasthenia gravis and reversal of paralytic agents

Organophosphates

irreversible anti-cholinesterase,

Cholinergic Drugs Adverse Effects Acronym

SLUDGE (Salivation/sweat, lacrimation, urination, defefaction, GI distress, emesis)