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Circumstantial evidence for DNA
Present in the nucleus of a cell and in chromosomes
Doubles during the S phase of the cell cycle
Diploid cells have twice as much as haploid cells
1868
nuclei was isolated from white blood cells of wounded soldiers and contained DNA
Early 1900s
DNA binding dyes developed
location of DNA found using light microscopy
amount of DNA found using flow cytometry
S, G2 , and M phase cells has double the DNA compared to G1 phase
haploid cells had ½ the DNA as diploid cells
Transformation experiment
found that DNA is required for bacteria to change their genetic makeup