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What are the 3 main types of Autoimmune Hemolytic Anemias (AIHAs)?
1. Cold Agglutinin Disease (CAD)
2. Paroxysmal Cold Hemoglobinuria (PCH)
3. Warm Autoimmune Hemolytic Anemia
What is Cold Agglutinin Disease (CAD)?
IgM to human RBC I antigen
What is Paroxysmal Cold Hemoglobinuria (PCH)?
IgG coats RBCs at cold temperature
What is Warm Autoimmune Hemolytic Anemia?
IgG coats RBCS at 37 C and cells are lysed
What is the main diagnostic test for Autoimmune Hemolytic Anemias (AIHAs)?
Direct antiglobulin test (DAT; Direct Coombs test)