NAVLE Dermatology

What are the 4 main anti-pruritic medications in dogs?

Apoquel (oclacitinib), Cytopoint (lokivetmab), Cyclosporing (Atopica), steroids (predisone)

What are the 2 main anti-pruritic medications in cats?

Cyclosporin, prednisolone

What is the key mediator and pathway of pruritus?

IL-31 and JAK/STAT pathway

What is Apoquel?

JAK inhibitor

What is Cytopoint?

Monoclonal antibody that binds to IL-31

What is Prednisone?

anti-inflammatory or immunosuppressive depending on dose

What is Cyclosporin?

Calcineurin inhibitor which suppresses cytokine IL-2

What route and how often is Apoquel administered?

Oral twice daily for two weeks then once daily

What route and how often is Cytopoint administered?

Subcut every 4-8 weeks

What route and how often is prednisolone administered?

Oral, depends on severity

What route and how often is Cyclosporin administered?

Oral twice daily, can be tapered

What is the onset of activity of prednisone?

within 24 hoursWha

What is the onset of activity of Cytopoint?

within 24 hours

What is the onset of activity of Apoquel?

within 24 hours

What is the onset of activity of Cyclosporin?

4 weeks in dogs, 2-3 weeks in cats

What are the side effects or contraindications of Apoquel?

Increase susceptibility to Demodex and other infections, may exacerbate neoplasia. Never use <1yo (infections)

What are the side effects of Cytopoint?

None specifically observed

What are the side effects and contraindications of Cyclosporin?

GI upset, hirsutism, papillomas, gingival hyperplasia. Should not use with P-glycoprotein (ivermectin)

What are the side effects and contraindications of prednisone?

PU, PD, PP, behavioural changes, GI ulcers, hepatopathy, diabetes, hyperlipidaemia, decreased thyroid hormone, delayed wound healing, cutaneous atrophy, comedones, 2° infections. Never use with NSAIDS (increases risk of GI ulcer and renal failure)