CHOLESTEROL SYNTHESIS

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13 Terms

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DMAPP and IPP

combined in the first step of cholesterol synthesis to form geranyl pyrophosphate

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prenyl transferase

first enzyme in cholesterol synthesis

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DMAPP

added to geranyl pyrophosphate to make farnesyl pyrophosphate

4
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prenyl transferase

catalyzes geranyl pyrophosphate + DMAPP → farnesyl pyrophosphate

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geranyl pyrophosphate

DMAPP + IPP →

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Farnesyl pyrophosphate

DMAPP + Geranyl pyrophosphate →

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Squalene

Farnesyl Pyrophosphate + Farnesyl Pyrophosphate →

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squalene synthase

catalyzes 2 Farenyl pyrophosphate + NAD + H+ → Squalene (NAD+ and 2PPi leave)

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squalene monooxygenase

catalyzes Squalene + O2 + NADPH + H+ → Squalene 2,3-epoxide (NADP+ and H2O leave)

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squalene 2,3-epoxide

Squalene + O2 + NADPH + H+ →

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squalene 2,3-epoxide

starting compound for the synthesis of sterols (still 20 steps from lanosterol to cholesterol)

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cyclase

catalyzes Squalene 2,3-epoxide → lanosterol

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lanosterol

squalene 2,3-epoxide →