Protein Synthesis Inhibitors

Flashcards about protein synthesis inhibitors, their mechanisms of action, and the ribosomal subunits they target.

What is the mechanism of action of Aminoglycosides?

Inhibits formation of initiation complex, causing the misreading of mRNA

Which ribosomal subunit do Aminoglycosides target?

30S

What is the mechanism of action of Tetracyclines?

Prevents attachment of aminoacyl-tRNA to acceptor site

Which ribosomal subunit do Tetracyclines target?

30S

What is the mechanism of action of Chloramphenicol?

Inhibits peptidyl transferase

Which ribosomal subunit does Chloramphenicol target?

50S

What is the mechanism of action of Macrolides?

Blocks aminoacyl-tRNA complex translocation step

Which ribosomal subunit do Macrolides target?

50S

What is the mechanism of action of Clindamycin?

Blocks initiation complex formation and inhibits aminoacyl-tRNA complex translocation step

Which ribosomal subunit does Clindamycin target?

50S

What is the mechanism of action of Linezolid?

Blocks formation of initiation complex

Which ribosomal subunit does Linezolid target?

50S

What bacterial ribosomal mRNA complex is disrupted by protein synthesis inhibitors?

70S

What ribosomal complex do eukaryotes utilize?

80S

What are the two subunits that compose the bacterial 70S ribosomal complex?

30S and 50S