Heme Lecture 1 : Introduction to Hematology
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8 Terms
1
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Origin of Blood Cells: Blast
\-Blasts committed to specific cell lines
\-No self-renewal
\-Morphologically recognizable
\-No self-renewal
\-Morphologically recognizable
2
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Embryonic Development & Hematopoiesis
is Developmental Blood Cell Production
3
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What are the Bone Marrow Sites & Functions?
\
There are -- forms of bone marrow
\-2, red and yellow
\
the liver, spleen and lymph nodes DO- revert back to producing blood cells in adults because if the bone marrow is packed with leukemic cells
There are -- forms of bone marrow
\-2, red and yellow
\
the liver, spleen and lymph nodes DO- revert back to producing blood cells in adults because if the bone marrow is packed with leukemic cells
4
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What is Bone Marrow?
Bone marrow is one of the largest organs in the body
\-is compromised of hematopoietic cells, adipose, osteoblasts, osteoclasts, and stroma
\-is compromised of hematopoietic cells, adipose, osteoblasts, osteoclasts, and stroma
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Where is Bone Marrow Located? (intramedullary hemopoiesis)
Found in the; skull, sternum, vertebrae, ribs, pelvis, proximal part of long bone
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What is the Normal Cellularity of Bone Marrow?
50% ratio between hematopoietic cells and fat cells
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Nuclear Changes of Blood Cells
→Nucleoli (RNA) immature
\-Chromatin
–open, lacy→ immature
–condensed→ immature
\-Shape
\-Chromatin
–open, lacy→ immature
–condensed→ immature
\-Shape
8
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Cytoplasmic Changes of Blood Cells
Look for:
\-Staining color / intensity
\-Granulation
\-Shape
\-Quantity
\-Vacuolization
\-Inclusion bodies
\-Staining color / intensity
\-Granulation
\-Shape
\-Quantity
\-Vacuolization
\-Inclusion bodies