17-L4- clotting and Platelets

Where are platelets formed

in bone marrow

whats the normal concentration of Thrombocytes

150-400 thousands/mm3

Steps to formaing platelets

Hemeocytoblast, Meyloid stem cells, Megakaryoblast, Megakaryocyte, thrombocyte

Hemostasis

series of reactions designed to stop bleeding

steps of Hemostasis

Vascular spasm, Platelet plug formation, coagulation, clot reaction

Whats the instric pathway

When all things needed for clotting are found in the blood

What is exsentric pathway

thromboplastin provides a shortcut

Fibrinolysis

Plasminogen become plasmin. Plasmin breaks down fiber mesh and phaygotic WBC removes products from clot dissolution

Prothrombin Time

a lab test were a patient’s blood clotting properties are tested

What happens if blood clots to fast

an anticoagulant may be prescribed

How long to thrombocytes last for

7-10 days

What are the steps to coagulation

prothrombin activator

prothrombin to thrombin

thrombin catalyzes the joining if fibrinogen into a fibrin mesh

What is platelet derived growth facotr

stimulates smooth muscle and fibrolus to repair the damages

What limits clotting in normal condition

rapid blood flow

antithrombinIII

What are the steps of Fibrinolysis

Tissue plasminogen Activator

Plasminogen to plasmin

Fibrin breaks down

What is a normal INR time

11-12.5 seconds

Hematoma

blood clot within tissue

Thrombus

Clot in an unbroken blood vessels

Embolus

a thrombus freely floating in the blood stream

how does asprin prevent excess clotting

inhibits thromboxane A

how does Heparin prevent excess clotting

activates antithrombinIII

how does warfarin prevent excess clotting

Vitam k is antoginis