tumor markers, antigens, human viruses assoc with can er

Burkitt lymphoma

Hodgkin lymphoma

Post-transplant lymphoproliferative disease

Nasopharyngeal carcinoma

Epstein barr virus

Hepatocellular carcinoma

Hepatitis B and C virus

Kaposi sarcoma

Human herpes virus 8

Cervical canver

Head and neck cancer

Other genitcal and anal cancer

Human papillomavirus

Adult T cell leukemia or lymphoma

Human t lymphocytic virus I

Shared TSA

Expressed in many tumors but not in most normal tissues

Differentiation ag

Expressed on immature cells of a particular lineage

Overexpressed antigens

Found in higher levels malignant cells than normal cells

MAGE (melanoma antigen gene)

Exampke of shared TSA

CD10

CEA (carcinoembryonic antigen)

AFP ( alphafetoprotein)

PSA (Prostate specific ag)

Ex of differentiation ag

HER2 (Human epidermal growth factor receptor 2

Ex of overexpressed ag

Ovarian cancer

CA 125

Breast cancer

CA 15-3

Pancreatic and gastrointestinal cancers

CA 19-9

Prostate cancer

PSA

Bone and liver cancer

Alkaline phosphatase

Neural tissue neoplasm

neuron specific enolase

•Germ cell carcinoma, trophoblastic Tumors

hCG

Medullary thyroid cancer

Calcitonin

Pancreatic ganstrinoma

Gastrin