Ceutics HW - Pseudo zero order kinetics

The intrinsic rate constant for the decomposition of ampicillin is 3× 10-5 min-1 at 25 °C. The solubility of ampicillin is 50 mg/mL. A suspension of ampicillin containing 200 mg/mL was prepared.

Ampicillin in this formulation will degrade by following __________________ order kinetics initially.

pseudo zero order

The intrinsic rate constant for the decomposition of ampicillin is 3× 10-5 min-1 at 25 °C. The solubility of ampicillin is 50 mg/mL. A suspension of ampicillin containing 200 mg/mL was prepared.

Once all solid ampicillin is consumed, drug degradation kinetics will be switched to _________ order.

first

The intrinsic rate constant for the decomposition of ampicillin is 3× 10-5 min-1 at 25 °C. The solubility of ampicillin is 50 mg/mL. A suspension of ampicillin containing 200 mg/mL was prepared.

What is the apparent rate constant during the rate process of a concentration decrease from 200 mg/mL to 50 mg/mL? Round the answer to 1st decimal point.


Answer: ____________ x 10-3 mg/(mL x min)

1.5

The intrinsic rate constant for the decomposition of ampicillin is 3× 10-5 min-1 at 25 °C. The solubility of ampicillin is 50 mg/mL. A suspension of ampicillin containing 200 mg/mL was prepared.

How long will it take for a concentration reduction from 200 mg/mL to 50 mg/mL? Unit in days. Round the answer to 1st decimal point.

69.4

The intrinsic rate constant for the decomposition of ampicillin is 3× 10-5 min-1 at 25 °C. The solubility of ampicillin is 50 mg/mL. A suspension of ampicillin containing 200 mg/mL was prepared.

How long will it take for a concentration decrease from 200 mg/mL to 20 mg/mL? Unit in days. Round the answer to 1st decimal point.

90.6

The intrinsic rate constant for the decomposition of ampicillin is 3× 10-5 min-1 at 25 °C. The solubility of ampicillin is 50 mg/mL. A suspension of ampicillin containing 200 mg/mL was prepared.

What will be the ampicillin concentration after 80 days? Unit is mg/mL. Round your answer to 1st decimal point.

31.5