Androgens

Androgens

male sex hormones

testosterone effects on female

Clitoral growth

Libido normal maintenance

virilization

virilization

Development of male characteristics in females caused by an overproduction of testosterone

increases skeletal muscle

testosterone anabolic effects

testosterone erythropoietic effects

Higher hematocrit --> increased thrombosis risk

Testosterone adverse effects

Virilization

Hepatotoxicity

Raise LDL

Premature epiphyseal closure

Acne/oily skin

Prostate cancer

Edema

Testosterone use considerations

Monitor RBC count, may cause chest pain, lowers sperm count and may cause infertility

Oral clinical androgens

Fluoxymesterone and Methyltestosterone

anabolic steroid risks

HTN

Sterility

Gynecomastia

Renal Damage

Intensify aggression

Sildenafil (viagra)

Prevents breakdown of cyclic GMP causing arterial dilation and engorgement

Sildenafil (viagra) complications

Dangerous if used concurrently with certain vasodilators (nitrates/alpha blockers)

Sildenafil (viagra) adverse effects

Hypotension

Priapism

Headaches

5-Alpha-reductase inhibitors

Inhibits 5-alpha reductase → reducing conversion into DHT; Effective in mechanical obstruction BPH

5-Alpha-reductase inhibitors types

Finasteride

Dutaseride

5-Alpha-reductase inhibitors adverse effects

Decreases ejaculate volume and libido

Gynecomastia

Alpha1-Adrenergic Antagonists

relaxes smooth muscle in the bladder neck to treat BPH

Alpha1-Adrenergic Antagonists types

Terazosin [Hytrin]

Doxazosin [Cardura]

Tamsulosin [Flomax]

Alpha1-Adrenergic Antagonists adverse effects

"Floppy iris syndrome" during cataract surgery

Decreased blood pressure