chemotherapy (oncology treatment)

chemotherapy is a ? treatment

systemic

chemotherapy drugs are ? and can kill the primary tumor cell and other tumor cells that have spread through the body

cytotoxic

what chemotherapy is a radio sensitizer and increases the effect of radiation

doxorubicin

what chemotherapy drug is a radio protector and decreases the effect of radiation on healthy cells

amifostine

(T/F) patient are more likely to have infections when undergoing chemotherapy

T

what chemotherapy is chemically similar to the structure of mustard gas and can burn skin if it comes in contact

alkylating agent

does alkylating agents depend on a specific cell cycle to be effective?

No

what do alkylating agents do?

they hinder the actions of nucleic acid and damages DNA so the cell stops reproducing

name one side effect of alkylating agent

bone marrow depression

nitrosoureas are a group of what?

alkylating agent

nitrosourceas also does what?

hinders a synthesis of DNA

does nitrosouceas depend on a specific cell cycle to be effective?

no

name one side effect of nitrosouceas

Delayed myelosuppression

G.I. toxicity

Delayed nephrotoxicity

which chemotherapy is lipid soluble and has the ability to cross the blood brain barrier and is typically used to treat brain tumors

nitrosourceas

nitrosouceas is typically used for cancer

brain tumor

anti metabolic work by…

disturbing the formation of new nucleic acids

are anti metabolic specific to a cell cycle?

yes

(T/F) anti metabolic are more effective with rapidly diving cells

T

anti metabolic are commonly used to treat what

leukemia

great

ovarian

intestinal tract cancer

anti-tumor Antibiotics Originate from where?

Microbial fermentation

(T/F) unlike Antibiotics, these drugs do not treat infections

T

anti-tumor antibiotics hinders what?

The transcription of DNA and RNA

anti-tumor anabiotic’s do not depend on a specific cell cycle, but is most effective in what two phases?

S phase

G2 phase

which type of chemotherapy drug remove or replaces naturally occurring hormones?

Hormonal agents

which agent is commonly used to treat breast cancer

hormonal agent

what is topoisomerase inhibitors?

They are plant alkaloids that interfere with enzymes to stop replication

what chemotherapy drug originate from the periwinkle plant

Vinka alkaloid

what do Vika alkaloid do?

They terminate cell replication in metaphase