Organic dust toxic syndrome

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6 Terms

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Definition

Acute, non-allergic, flu-like illness after heavy inhalation of organic dust (e.g. grain, mouldy hay, wood chips).

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Pathogenesis

Caused by endotoxins, mycotoxins and microbial products; not immune-mediated (distinguishes from hypersensitivity pneumonitis).

Cytokines and complement Cascade. Not immunological

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Clinical features

Fever, chills, myalgia, malaise, cough, chest tightness; occurs 4–12 hrs after exposure.

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Investigations

Normal chest X-ray and lung function; neutrophilia common, no specific antibodies

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Prognosis

Self limiting

No antibiotics or steroids

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List 3 inhalation fevers

  1. Metal fume fever

  2. Polymer fume fever

  3. Organic dust toxic syndrome