DNA repair
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34 Terms
what are the 5 types of ssDNA damage repair
MMR, BER, NER, direct reversal, translesion DNA synthesis
In MMR, what protein binds to mismatched bases
MutS
what protein does MutS form a complex with
MutL
what does MutS-MutL complex scan for
hemimethylated DNA
what protein does MutS-MutL complex recruit
MutH
what kind of enzyme is MutH
endonuclease
which DNA Pol in prokaryotes synthesises missing sequence in MMR
DNA Pol 1
In BER, what enzyme flips incorrect nucleotide out of DNA helix
DNA glycosylase
what does DNA glycosylase do after flipping base out of helix
cleaves it
what enzyme cleaves phosphodiester bonds in BER
AP endonuclease
which DNA Pol in prokaryotes fills in missing nucleotide during BER
DNA Pol 3
In NER, what protein scans genome to identify nucleotide errors
UvrA
When UvrA find mistake what protein does it recruit
UvrB
what do UvrAs do after UvrA-UvrB complex binds to DNA
leave
what does UvrB do
verifies damage
what protein is recruited after UvrB
UvrC
what type of enzyme is UvrC
endonuclease
what protein is recruited after UvrC
UvrD
what type of enzyme is UvrD
helicase
what is the simplest type of ssDNA damage repair
direct reversal
what are the two types of direct reversal
photoreaction, methyl group removal
what kind of damage does photoreaction fix
pyrimidine dimers
what enzyme binds to pyrimidine dimers
photolyase
what does photolyase absorb
light
what kind of bonds does photolyase break
covalent bonds
what enzyme removes methyl groups from guanines
Methylguaninemethyl transferase (MGMT)
to what residue is methyl transferred to on MGMT
cysteine
Note 
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