El-sayed: phenols and nucleoside antifungals

phenol antifungal MOA

interferes with the cell membrane integrity and the function of fungi

name the phenol antifungals

Salicylic acid

haloprogin

Ciclopirox olamine

Clioquinol

is salicylic acid strong or weak

STRONG

why is salicylic acid strong

intramolecular H bonding

indication of salicylic acid

external use for corns and athletes foot

haloprogin must be protected from ___-

light

dose/form of haloprogin

1% cream or solution

indication of haloprogin

superficial tinea infection

Ciclopirox olamine is used topically for

dermatophytes and candida

Ciclopirox olamine is the first line tx for

o   T. corporis

o   T. cruris

o   T. pedis

Ciclopirox olamine is the second line tx for

Onychomycosis

low doses of Ciclopirox olamine lead to

blocking fungal amino acid transport

high doses of Ciclopirox olamine lead to

disruption of fungal membrane integrity

color of Clioquinol

yellow/white

protect Clioquinol from ____

light

dosage forms of Clioquinol

powder and 3% ointment

Clioquinol powder indication

Atopic dermatitis

Eczema

Psoriasis

Impetigo

Clioquinol 3% ointment indication

T. vaginitis infections

Clioquinol is mostly used for

athletes foot

what is the nucleoside analog antifungal

Flucytosine

indication of Flucytosine

systemic mycoses

Flucytosine is not ___ or ____

active

cytotoxic

Flucytosine is a ____

prodrug

Flucytosine is activated by____

fungal cytosine deaminase

when Flucytosine is activated by fungal cytosine deaminasee, what is it turned into

5-fluorouracil (5-FU)

5-fluorouracil (5-FU) is ____

cytotoxic

anticancer

5-fluorouracil (5-FU) is then transformed into

5-fluorodeoxyuridine

what is 5-fluorodeoxyuridine

thymidylate synthetase inhibitor

what does 5-fluorodeoxyuridine do

Interferes with fungal protein and RNA synthesis

do humans have cytosine deaminase

NAUR

some human bacterial flora can convert Flucytosine into…

5-FU