The Big 7: Hepatitis B; Respiratory Syncytial Virus (RSV); COVID-19

What is Hep B?

A liver infection caused by the hepatitis B virus (HBV)

How is Hep B transmitted?

When the blood, semen, or other body fluids of an infected person enter the body of someone who is not infected

What is the brand for Hep B vaccines?

Recombivax HB (Merck), Engerix-B (GSK), HEPLISAV-B (Dynavax), PreHevbrio (VBI Vaccines)

The brand Recombivax HB (Merck) and Engerix-B (GSK) is for which population?

Infants, adolescents, and adults

Recombivax HB (Merck) and Engerix-B (GSK) has how many doses for both children and adults?

3 doses

When should infants get the Hep B vaccine?

0, 1-2 months, 6 months

What is the dosage and route of administration for Recombivax HB (Merck) and Engerix-B (GSK)?

0.5 mL and IM

What is the earliest age to get the Hep B vaccine?

Birth

The brand PreHevbrio (VBI Vaccines) and HEPLISAV-B (Dynavax) is for which population?

Adults > 18 years old

What is the dose series for HEPLISAV-B (Dynavax)?

2 doses 1 month apart

What is the dosage and route for HEPLISAV-B (Dynavax)?

0.5 mL IM

What is the dose series for PreHevbrio (VBI Vaccines)?

3 doses at 0, 1, 6 months or adults > 18 years

What is the dosage and route of administration for PreHevbrio (VBI Vaccines)

1.0 mL and IM

What is the ACIP recommendation for Hep B vaccine?

Almost everyone gets the vaccine

What if a healthcare providers titer is zero for Hep B?

Give one dose, wait 1 month and repeat titer OR If high, no more doses needed OR If low or none, complete series, then repeat titer.

What is Respiratory Syncytial Virus (RSV)?

Common respiratory virus that usually causes mild, cold-like symptoms

What is the earliest age for infants to receive the RSV vaccine?

Birth

How is RSV transmitted?

Spread person to person via respiratory droplets

What is the ACIP recommendation for infants for RSV?

Infants younger than age 8 months born during or entering their first RSV season should receive one dose of nirsevimab or clesrovimab during October through March

What is the ACIP recommendation for pregnant women for RSV?

During 32 through 36 weeks gestation, with

seasonal administration September through January in most of the continental United States. In jurisdictions with seasonality that differs (e.g., those with tropical climates, Alaska), providers should follow state, local, or territorial guidance on timing of administration

What is the RSV brand for pregnant women?

RSVPreF (Abrysvo - Pfizer)

When should pregnant women receive the RSV vaccine?

32 through 36 weeks through September through January

What is the brand for adults for RSV?

Abfysvo (Pfizer), Arexvy (GSK), and mResvia (Moderna)

Who is Bivalent RSVpreF (Abrysvo) for?

60 years and older, 32 through 36 weeks gestational age of pregnancy

Who is Adjuvanted RSVPreF3 (Arexvy) for?

50-59 years and older

Who is Nucleoside modified mRNA encoding the RSV F glycoprotein stabilized in pre F protein - mRNA- 1345 (mRESVIA) for?

60 years and older. Individuals 18 through 59 years of age who are at increased risk for LRTD caused by RSV

What is the dosage and route of administration for adults for RSV vaccine?

0.5 mL and IM

What is the ACIP recommendation for adults for RSV vaccine?

Adults aged ≥75 years and adults aged 50-74 years who are at increased risk of severe RSV disease receive a single dose

What are examples of chronic medical conditions and other risk factors associated with increased risk of severe RSV?

Chronic cardiovascular disease, chronic lung or respiratory disease, liver disease, etc

When should adults get the RSV vaccine?

August to October

It is September. Mariana is a 30-year-old that is 27 weeks pregnant with no significant past medical history. She is up-to-date on all her immunizations as of the beginning of her pregnancy in March, including the COVID-19 vaccines. She asks you to review her full vaccination needs. What are your recommendations?

Tdap and inactive influenza shot

What is COVID-19?

Respiratory illness caused by a novel coronavirus

How is COVID-19 transmitted?

Spreads primarily through close contact when an infected person exhales virus-containing respiratory droplets and tiny particles that can be inhaled by others or land in their eyes

What is the earliest age to get the COVID-19 vaccine?

6 months

Can pregnant women receive the COVID-19 vaccine?

No

What is the COVID-19 vaccine recommendation?

Shared clinical decision-making for healthy children ages 6 months-17 years

What is the two different kinds of COVID-19 vaccine?

mRNA vaccine and protein subunit

What is the brand of COVID-19 mRNA vaccine?

PfizerBioNTech and Moderna

What is the brand of COVID-19 protein subunit vaccine?

Novavax

For Novavax COVID-19 vaccine, what are the kinds provided?

Approval NUVAXOVID

For PfizerBioNtech vaccine, who is it for?

EUA for 6 months to 11 years AND Approval Comirnaty for 12 years and over

For moderna COVID-19 vaccine, what are the kinds provided?

Approval Spikevax and mNEXPSIKE

Who is Spikevax for?

6 months to 64 years of age with at least one condition that puts them at increased risk for COVID-19 and all adults 65 years and older

Who is mNEXSPIKE for?

Individuals who have been previously vaccinated with COVID-19. 12 months to 64 years of age with at least one condition that puts them at increased risk for COVID-18. All adults 65 years and older

Who is Novavax for?

Ages 12-64 years with at least one underlying condition that puts them at high risk for severe COVID-19. All adults ages 65 years and older

What is Spikevax?

Codes for the whole spike protein of SARS-CoV-2, for > 65 years, and for 6 months to 64 years with at least one condition that puts them increased risk for severe outcomes from COVID-19

What is the dosage and route of adminstration for Spikevax?

0.5 mL and IM

What is mNEXSPIKE?

Codes for the N-terminal domain and the receptor-binding domain of the spike protein of the virus, for > 65 yrs, and for 12-64 yrs who have a condition that

puts them at high risk for severe outcomes from COVID-19

What is the dosage and route of administration for mNEXSPIKE?

0.2 mL and IM

Why is mNEXSPIKE have a smaller dose?

Has more of a reactive protein in the vaccine

Who is the 2025-26 COVID-19 vaccine approved for?

Infants and children age 6-23 months, person 2-64 years old if high risk of severe COVID-19 including pregnant, and adults > 65 years with moderate or severe immuncompromise