Postpartum Meds

OB/LD CU NSG 3010

Cytotec (misoprostol)

• Prostaglandin

• Postpartum hemorrhage (uterine atony)

• Rectal, PO, Sublingual

• Contraindications & Cautions

  • Not be used to prevent NSAID-induced gastric injury due to potential for fetal harm or death. May cause severe diarrhea in the nursing infant. Hypersensitivity to prostaglandins.

• Side effects

  • Abd. pain

  • Diarrhea

  • Miscarriage

  • Constipation

  • Dyspepsia

  • Flatulence

  • N/V

  • Menstrual disorders

  • HA

• NSG considerations

  • educate pt on side effects

  • Not 1st or 2nd line treatment

Lysteda (transexamic acid/TXA)

• antifibrinolytic agent

• postpartum heorrhage

• IV

• Considerations & Cautions

  • thromboembolic disoders

  • acquired defective color vision

  • Caution

    • renal impairment

    • hematuria

    • use of hormonal contraceptive

• Side effects

  • HA

  • pain

  • seizures

  • anaphylaxis (PO usually)

  • visual abnormalities

  • HoTN

  • thromboembolism

  • N/V/D

• NSG Consisderations

  • give first few hours after delivery to inhibit enzymatic breakdown of fibrin blood clots

Methergine (methylergonovine)

Uterine stimulant (oxytocic) 

Methergine (methylergonovine)

Postpartum Hemorrhage: Stimulates sustained/tetanic contraction of the uterus 

Methergine (methylergonovine)

Avoid if patient has elevated blood pressure

Methergine (methylergonovine)

Raises patient BP/HTN, 

Stroke, N/V, cramps 

Methergine (methylergonovine)

Common second choice drug for uterine atony