Beta oxidation of fatty acids

0.0(0)
studied byStudied by 0 people
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
Card Sorting

1/6

encourage image

There's no tags or description

Looks like no tags are added yet.

Study Analytics
Name
Mastery
Learn
Test
Matching
Spaced

No study sessions yet.

7 Terms

1
New cards

Step 1(Activation of fatty acid)

A fatty acid is activated in the cytosol by the addition of CoA-SH and by enzyme acyl-CoA synthetase, using ATP. Resulting in acyl-CoA

2
New cards

Step 2

Using enzyme CAT-1, carnitine attaches to the molecule and CoA-SH is kicked off to form acylcarnitine so that it can be transported into the mitochondria.

3
New cards

Step 3

In the mitochondria, CAT-2 enzyme adds CoA-SH to the molecule and carnitine is kicked off to regenerate acyl-CoA for subsequent beta oxidation.

4
New cards

Step 4

The acyl-CoA is oxidized into enoyl-CoA by the enzyme acyl-CoA dehydrogenase, introducing a double bond. NAD+ is reduced to NADH in the process.

5
New cards

Step 5

The enoyl-CoA undergoes hydration by the enzyme enoyl-CoA hydratase, adding a water molecule to form beta hydroxyacyl-CoA.

6
New cards

Step 6

The beta hydroxyacyl-CoA is oxidized to form beta ketoacyl-CoA by the enzyme beta-hydroxyacyl-CoA dehydrogenase, reducing NAD+ to NADH.

7
New cards

Step 7

The beta ketoacyl-CoA undergoes thiolysis, cleaved by the enzyme thiolase and a CoA-SH is added resulting in the formation of a free fatty acyl-CoA and an acetyl-CoA molecule.