Prelims on UNIT 1

Pharmacokinetics

Body does to a drug

onset, intensity, and duration of drug action

Four pharmacokinetic properties determines;

Absorption

Distribution

Metabolism

Elimination

what are the Four pharmacokinetic properties determine the onset, intensity, and duration of drug action

Aqueous

Nonpolar

Low molecular weight

Unionized

4 requirements of extracellular and intracellular nature of cell membranes

cell membrane

a thin barrier that surrounds the cell and controls what enters and exits

phospholipid bilayer

structure of cell membrane

drug cross the membrane through different transport mechanisms to reach their target

why is the cell membrane important in drugs?

Passive diffusion

movement of a drug from higher conc to lower conc and does not involved a carrier(no helper protein)

Passive diffusion

Not saturable and shows low structural specificity

water-soluble drugs

lipid- soluble drugs

two ways happen in passive diffusion

Water-soluble drugs

pass through pores or channels in membrane

Lipid-soluble drugs

dissolve directly into the membrane and pass through

Passive diffusion

Facilitated diffusion

Active transport

Endocytosis and Exocytosis

Modes of permeation and transport

Facilitated Diffusion

Movement of large molecule though specialized transmembrane carrier proteins

Facilitated Diffusion

Does not require energy

saturated

Facilitated Diffusion

inhibited by compounds that compete for the carrier