Loop Diuretics

loop diuretics target tubular cells of __________.

loop of henle

approximately __________% of sodium is reabsorbed in the Loop of Henle.

25%

the __________ cotransporter draws Na+, K+, and 2 Cl- into cells in the Loop of Henle.

Na+/K+/Cl-- cotransporter

in the Loop of Henle, Na+ is transported into the __________ space between capillaries and tubular cells.

interstitial

loop diuretics create a __________ environment around the capillaries in the Loop of Henle.

salty

water moves from the tubular lumen into the interstitial space via __________ channels.

aquaporins

K+ moves back into the tubular lumen, creating a __________ charge.

positive

Ca2+ and Mg2+ move __________ between cells into the interstitial space.

paracellularly

the mechanism that removes NaCl from ascending limb and water from descending limb is called __________.

counter-current multiplier mechanism

loop diuretics inhibit the __________ in the ascending limb.

Na+/K+2Cl- cotransporter

examples of Type I loop diuretics include __________, __________, and __________.

furosemide, torsemide, bumetanide

an example of a Type II loop diuretic is __________.

ethancrynic acid