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input zone and parts
where neurons collect and integrate information, either from the environment or from other cells; dendrites, cell body
integration zone
where the decision to produce a neural signal is made
conduction zone & parts
where information can be transmitted over great distances; axon
output zone & parts
where the neuron transfers ifnormation to other cells; axon terminals
Motoneurons (motor neurons)
stimulate muscles or glands
sensory neurons
respond to environmental stimuli, such as light, odor, or touch
interneurons
receive input from and send input to other neurons, tend to be multipolar neurons
What are the 3 components of a synapse?
presynaptic membrane, synaptic cleft, postsynaptic membrane
presynaptic membrane
on the exon terminal of the presynaptic neuron
synaptic cleft
a gap that separates the membranes
postsynaptic membrane
on the dendrite or cell body of the postsynaptic neuron
synaptic vesicles
small spheres in presynaptic axon terminals that contain a neurotransmitter
What determines the release of neurotransmitters?
Neurotransmitters release in response to electrical activity in the axon
receptors
in the postsynaptic membrane, specialized proteins that react to a neurotransmitter
dendritic spines
outgrowths that are studded across the dendrite which increase surface area
What determines the number and structure of dendritic spines?
they can be rapidly altered by experience, facilitating the continual remodeling of connections between neurons (neural plasticity)
At what point is neural plasticity at its height?
during childhood
axon hillock
a cone-shaped area of the cell body that gives rise to the axon
axonal transport
the movement of materials within an axon via motor proteins
Glial Cells
support and enhance neural activity, they can communicate with each other and neurons
What are the 4 different types of glial cells?
astrocytes, microglial cells, oligodendrocytes, schwann cells
Astrocytes
star shaped cells with many processes that receive neuronal input and monitor activity. Controls flow of resources
microglial cells (microglia)
small cells that remove debris from dead, damaged cells; debris from nervous system. If job is not being done correctly then brain debris buildup can occur. CLEAN UP CREW!
Oligodendrocytes
glial cells that form myelin sheath in the brain and spinal cord
schwann cells
provide myelin to cells outside brain and spinal cord
myelination
the process in which glial cells wrap axons with a fatty sheath, myelin, to insulate and speed conduction
Nodes of Ranvier
gaps between sections of myelin where the axon is exposed
What happens if too many glial cells divide?
tumors can form
How do glial cells respond to injury?
edema/swelling
Astrocytes influence brain chemistry and have been implicated in ____
epilepsy
Microglia have been implicated in…
degenerative diseases, such as Alzheimer’s. Can be due to microglia not doing an adequate job or not having enough.
multiple sclerosis
a demyelinating disease
Peripheral Nervous System (PNS)
all parts of the nervous system found outside the skull and spinal column. Consists of nerves.
Central Nervous System (CNS)
consists of brain and spinal cord. Some nerves, motor nerves, transmit information from here to the muscles, organs, and glands. Sensory nerves also convey information from the body to here.
The nerves of the body are divided into what 2 systems?
somatic and autonomic nervous system
Somatic nervous system
nerves that interconnect the brain and the major muscles and sensory systems
Autonomic nervous system
nerves that primarily control the viscera
cranial nerves
12 pairs; some of which are exclusively sensory nerves, some are exclusively motor nerves, while some have both functions
spinal nerves
or somatic nerves, 31 pairs
each spinal nerve is the fusion of two distinct branches, or roots which are?
dorsal (back) root & ventral (front) root
dorsal (back) root
carries sensory information from the body to the spinal cord
ventral (front) root
carries motor information from the spinal cord to the muscles
sympathetic nervous system
this activation prepares the body for action (fight or flight)
parasympathetic nervous system
this activation is often in opposition to sympathetic activity. Rest and digestion
cerebral cortex
the thick, outermost sheet of the cerebral hemispheres, comprised mostly of neuronal cell bodies, dendrites, and axons.
gyri (gyrus)
ridges or riased portions of the convoluted brain surface
sulci (sulcus)
furrows of the convoluted brain surface (sulking-low)
sagittal plane
bisects the body into right and left halves
coronal plane
divides the body into front (anterior) and back (posterior) regions
horizontal plane
divides the brain into an upper and lower part
medial
towards the middle
lateral
towards the side
Ipsilateral
same side
Contralateral
opposite side
anterior or rostral
head end
posterior or caudal
tail end
proximal
near the center
distal
toward the periphery
afferent
carrying information into a region of interest
efferent
carrying information away from a region of interest
frontal
most anterior region
parietal
region between the frontal and occipital lobe
occipital
posterior region, visual processing
temporal
lateral region, auditory processing
sylvian fissure (lateral sulcus)
boundary of the temporal lobe
central sulcus
divides the frontal lobe from the parietal lobe
postcentral gyrus
strip of cortex behind the central cortex that is important for touch
precentral gyrus
in the frontal lobe, important for motor control
corpus callosum
a bundle of axons that connects the two cerebral hemispheres, allows for brain hemispheres to share information
basal ganglia
important in motor control. includes caudate nucleus, putamen, and globus pallidus
limbic system
includes structures important for learning and memory: amygdala, mammillary bodies, hippocampus, fornix (memory) and septal nuclei (reward & reinforcement in learning)
what are the 2 main components of the diencephalon?
thalamus and hypothalamus
thalamus
cluster of nuclei that relays sensory information
hypothalamus
contains nuclei with many vital functions; also controls pituitary
cerebellum
elaborately convoluted; involved in motor coordination and learning; consists of three layers
pons
attached to the cerebellum and contains motor control and sensory nuclei and gives rise to cranial nerves
medulla
contains cranial nerve nuclei and marks the transition from brain to spinal cord. contains nuclei that regulate breathing and heart rate. all axons from the brain to the spinal cord pass through here.
The brain and spinal cord are surrounded by three protective membranes, the meninges which are:
dura meter, pia meter, arachnoid
dura mater
tough outermost sheet of protective membrane
pia mater
delicate innermost protective membrane layer
arachnoid
substance between the dura mater and pia mater that cushions the brain is cerebrospinal fluid.
ventricular system
a series of chambers filled with cerebrospinal fluid
what is the function of cerebrospinal fluid?
acts as a shock abosrer and provides an exchange medium between blood & brain
action potential
a rapid electrical signal that travels along the axon of a neuron, triggers the release of neurotransmitters
neurotransmitter
a chemical messenger between neurons that is released into synapses
resting membrane potentional
-50 to -80 mV that shows the negative polarity of the cell’s interior
The neuron shows selective permeability meaning..
it allows K+ to freely enter or leave the cell, but restricts the flow of other ions
diffusion
causes ions to flow from areas of high to low concentration, along their concentration gradient
electrostatic pressure
causes ions to flow towards oppositely charged areas
sodium-potassium pump
neurons use this mechanism to maintain resting potential. Pumping 3 Na+ ions out for every 2 K+ pumped in. (this is a pump therefore an active process)
At rest ___ channels are open, while ___ channels are closed.
Potassium; Sodium
action potentials are brief but large changes in the? Which originate in the?
membrane potential; axon hillock
Patterns of action potentials
carry information to postsynaptic targets
hyperpolarization
an increase in membrane potential- the interior of the membrane becomes even more negative , relative to the outside
depolarization
a decrease in membrane potential- the interior of the cell becomes less negative. (if depolarized enough, a cell will fire)
graded response
the change in potential; the greater the stimulus the greater the response
action potentials are produced by the movement of what ions?
Na+ ions
refractory period
time when only some stimuli can produce an action potential
absolute refractory phase
time when no action potentials are produced