Loci Inheritance / Monohybrid Crossing

What is locus/loci?

Particular segment of DNA fragment that codes for a specific gene product

What occurs when loci are close together on a chromosome?

They tend to segregate (be inherited) together as no crossing over occurs

What occurs when loci are far apart on a chromosome?

Have a greater chance for recombination and crossing over (exchange of nucleotides)

What is linkage disequilibrium (non-random association between alleles)

When certain combination of alleles are found together more or less often than expected by chance

So when is LD (linkage disequilibrium) strong and when is it weak?

• Strong LD = close loci (less recombination)

• Weak LD = far apart loci (more recombination)

What is 1-Locus inheritance or Monohybrid Crossing

Inheritance pattern of a single gene (at one locus) with 2 alleles:

• One dominant

• One recessive

Producing offspring like crossed (Aa)