Immunology CD Markers, Cytokines, Complement

Naive T cell

CD3 (all), CD28, TcR

Activated T cell

CD3 (all), CD28, TcR, CD25

CD40L on T helper cells

Th1 (T helper cell)

CD4

Key products: IL2, IFNγ, TNF

Th2 (T helper cell)

CD4

Key products: IL4, IL5

Tfh (T follicular cell)

CD4

Key products: IL4

Th17 (T helper cell)

CD4

Key products: IL17

Treg (Regulatory T cells)

FOXP3 Transcription Factor

Key products: IL10, TGFβ

1CTL (Cytotoxic T Lymphocyte)

CD8, FasL

Key products: granzymes, perforin

B lymphocytes

sIg, CD19, CD20, CD80, CD86, Fas, CD40

Key products: antibodies

Natural Killer Cells

CD56, CD19 (binds to the Fc portion of IgG antibodies on opsonized cells - ADCC)

Key products: granzymes, perforin

Monocytes and Macrophages

CD14, CD80, CD86, Fas, CD40

Key products: inflammatory cytokines

Dendritic Cells

CD11, CD80, CD86, CD40

Key products: inflammatory cytokines

HSC (Hematopoietic stem cells)

CD34

IL1, IL6 Function

Inflammation

IL2 Function

Function: T cell growth factor

IL4, IL5 Function

Function: humoral immunity

IL10 and TGFβ Function

Function: anti-inflammatory, immunoregulation

IL17 Function

Function: anti-bacterial, anti-fungal

IFNα and IFNβ Function

Function: anti-viral

IFNγ Function

Function: cell-mediated immunity

TNF (Tumor necrosis factor) Function

Function: inflammation, cell-mediated immunity

Perforin and Granzyme Function

Function: cytolysis

C1 Protein Function

Function: initiates classical C’ pathway by finding to antibody Fc region

C2 and C4 Protein Function

Function: early part of classical C’ pathway

• C2 and C4 are cleaved

C3 Protein Function

Function: opsonization, MAC formation

• C3 is cleaved into C3a and C3b. C3b is for opsonization

C3a product: inflammation

C5 Protein Function

Function: Is cleaved into C5a and C5b

C5a product: inflammation

C5b + C6-9 Protein Function

Function: Membrane attack complex forms. Osmotic lysis of microbe

CRP (C-reactive protein) Function

Function: an acute phase protein and a marker of inflammation (non-specific)

CAN ALSO ACTIVATE CLASSICAL C’ PATHWAY, ACTING AS AN OPSONIN AND AS A COMPLEMENT ACTIVATOR

B and D Protein Function

Function: initiates alternative C’ pathway

MBP (mannose-binding protein) Function

Function: initiates lectin C’ pathway

C1-IHN (C1 esterase inhibitor) Protein Function

Function: inhibits inappropriate activation of classical C’ pathway