WK 3 -2

Testosterone

An androgen that binds to androgen receptors, converted to DHT, and stimulates male development.

Adverse effects of Testosterone

Common effects include acne and increased RBC count; rare effects include liver toxicity.

Indications for Testosterone

Used for hypogonadism, delayed puberty, and hormone replacement therapy (HRT).

Contraindications for Testosterone

Contraindicated in prostate cancer and severe cardiac or liver disease.

Testosterone Undecanoate

An androgen ester that slowly releases testosterone for longer-lasting effects.

Adverse effects of Testosterone Undecanoate

Common effects include fluid retention and mood changes; rare effects include pulmonary oil microembolism.

Indications for Testosterone Undecanoate

Used for testosterone replacement therapy.

Contraindications for Testosterone Undecanoate

Contraindicated in prostate cancer and uncontrolled hypertension.

Cyproterone Acetate

An anti-androgen that blocks androgen receptors to inhibit testosterone effects.

Adverse effects of Cyproterone Acetate

Common effects include fatigue and low libido; rare effects include liver dysfunction.

Indications for Cyproterone Acetate

Used for prostate cancer, severe hirsutism, and chemical castration.

Contraindications for Cyproterone Acetate

Contraindicated in liver disease and depression.

Finasteride

A 5-alpha reductase inhibitor that prevents testosterone conversion to DHT.

Adverse effects of Finasteride

Common effects include erectile dysfunction and decreased libido; rare effects include breast tenderness.

Indications for Finasteride

Used for benign prostatic hyperplasia (BPH) and androgenic alopecia.

Contraindications for Finasteride

Contraindicated in pregnancy (especially for women handling crushed tablets).

Ethinylestradiol

An estrogen that activates estrogen receptors, suppressing FSH and inhibiting ovulation.

Adverse effects of Ethinylestradiol

Common effects include nausea and headache; rare effects include blood clots (DVT/PE).

Indications for Ethinylestradiol

Used for combined oral contraception and hormone replacement therapy (HRT).

Contraindications for Ethinylestradiol

Contraindicated in history of thromboembolism and breast cancer.

Estradiol

An estrogen that mimics natural estrogen, regulating reproductive function.

Adverse effects of Estradiol

Common effects include breast tenderness and bloating; rare effects include stroke.

Indications for Estradiol

Used for hormone replacement therapy, menopause symptoms, and osteoporosis prevention.

Contraindications for Estradiol

Contraindicated in history of stroke and estrogen-sensitive cancers.

Norethindrone

A progestogen that activates progesterone receptors, inhibiting ovulation and thickening cervical mucus.

Adverse effects of Norethindrone

Common effects include irregular bleeding and weight gain; rare effects include blood clots.

Indications for Norethindrone

Used for contraception and hormone replacement therapy (HRT).

Contraindications for Norethindrone

Contraindicated in severe liver disease and history of thrombosis.

Mifepristone (RU486)

A progesterone antagonist that blocks progesterone receptors to induce pregnancy termination.

Adverse effects of Mifepristone

Common effects include nausea and heavy bleeding; rare effects include sepsis.

Indications for Mifepristone

Used for medical abortion.

Contraindications for Mifepristone

Contraindicated in ectopic pregnancy and adrenal insufficiency.