WBC Exam - Lymphoid Neoplasms

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11 Terms

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Lymphoid Neoplasms

90% lymph (>20% lymphoblast)

CD13-, CD33-, CD10+

PAS+

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B Cell ALL

proB: Tdt+, HLA-DE+, CD19, CD79a

intermediate pre B: CD10

preB: CD20, sCD22

childhood = t(12;21)

adults = t(9;22), BCR/ABL1

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T Cell ALL

Tdt +, CD7, CD3

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Chronic lymphocytic leukemia (CLL)

CD5, CD23

weakly CD20 and sIg+

LEF-1+

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B-cell prolymphocytic leukemia (B-PLL)

CD5 variable, CD20 and sIg intense, FMC-7+, CD19, CD22

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Hairy cell leukemia

TRAP+

CD19, CD20, sIg +

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Mantle cell lymphoma

resembles CLL but CD23- and LEF-1 -

CD19, CD5, sIg, FMC-7+

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Lymphoplasmacytic Lymphoma (LPL)

lack lytic bone lesions

waldenstrom macroglobulinemia

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Burkitt Lymphoma

CD19, sIg+, CD10

CD5-, Tdt-

t(8;14)

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Multiple myeloma

CD19, CD20, CD56, sIg+

CRAB — hypercalcemia, renal insufficiency, anemia, lytic bone lesionsM

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MGUS

no symptoms

low level serum or urine monoclonal protein without overt neoplasms