Beta Oxidation of Fatty Acids

Where does Fatty Acid Oxidation occur?

Heart Muscle

Skeletal Muscle

Liver

Describe the Activation Step.

Fatty Acids enter the cell and reacts with Fatty Acyl CoA Synthetase which adds CoA and converts ATP into ADP turning it into Fatty Acyl CoA.

Describe the Transport Step.

Fatty Acyl CoA reacts with Carnitine and C.A.T-I which releases CoA-SH and converts it into Fatty Acyl Carnitine.

Describe the step leading up to B-oxidation.

Fatty Acyl Carnitine reacts with CAT-II which adds CoA-SH and releases the carnitine molecule.

What is the first step of B-Oxidation?

Fatty Acyl CoA reacts with Acyl CoA DH.

FAD gets converted into FADH2

Produces Enoyl CoA

Dehydrogenation Reaction

What is the second step of B-Oxidation?

Enoyl CoA reacts with Enoyl CoA Hydratase and H20

Produces B-Hydroxy-Acyl-CoA

Hydration Reaction

What is the third step of B-Oxidation?

B-hydroxy-acyl-CoA reacts with B-hydroxy-acyl-CoA DH

NAD+ gets converted into NADH

Produces B-keto-acyl-CoA

Dehydrogenation Reaction

What is the fourth step of B-Oxidation?

B-keto-acyl-CoA reacts with Thiolase which cuts the molecule at the B carbon.

CoA-SH gets added

Produces Fatty Acid CoA and Acetyl-CoA

What happens to the Fatty Acid CoA?

It gets recycled back into B-Oxidation

What happens to the Acetyl-CoA?

It gets used in the Krebs cycle

How many rounds of B-Oxidation take place?

7

How many Acetyl CoAs are produced?

8