VPTH 123 CLINICAL PATHOLOGY

Prolonged storage of blood in EDTA blood tubes can cause swelling of neutrophils only.

FALSE

Bovine erythrocytes are similar in size to feline erythrocytes and have small amount of central pallor.

TRUE

Cytologic slides can be stored in transport chest together with other samples.

FALSE

Left shift in most situations indicates inflammatory leukogram

TRUE

Acidic structures, such as DNA/RNA or basophil granules are stained blue by basic stain.

TRUE

Non-regenerative anemia is caused by persistent hemolysis.

FALSE

Mean corpuscular hemoglobin is a measure of the average RBC size.

FALSE

Water artifact in blood smears is characterized by irregular punched out areas in red blood cells.

TRUE

Slow venipuncture can induce small microclots within the sample.

TRUE

Physiologic leukogram consists of neutrophilia, left shift, lymphocytosis and monocytes within reference range.

FALSE

The primary functional role of RBC is to transport oxygen from the tissues to the lungs and carbon dioxide from lungs to the tissues for expulsion.

FALSE

Samples collected for microbiology laboratory tests should be stored in the freezer.

FALSE

White blood cell morphologic features are less species-dependent than red blood cells.

TRUE

Large numbers of spherocytes in blood smears indicate immune-mediated anemia.

TRUE

Prolonged storage of blood can cause hemoglobin crystallization.

TRUE

Mast cells if present in the blood smear are seen in the feathered edge.

TRUE

Pancytopenia is characterized by non-regenerative anemia and neutropenia.

FALSE

Absolute erythrocytosis due to dehydration or hemoconcentration accompanied by an increased total protein.

FALSE

relative - dehydration

absolute - bone marrow

Animal species demonstrate marked variability in the size of their erythrocytes.

TRUE

Most lymphocytes in blood are short-lived cells that recirculate between blood and tissue.

FALSE

long-lived

Erythrocytes with a blister-like vesicle are called acanthocytes.

FALSE

keratocytes

Acute inflammation leukogram consists of neutrophilia, increased left shift, lymphopenia, normal monocytes with evidence of inflammation.

FALSE

Monocytes do not have storage pool in the bone marrow.

TRUE

Impression smears are indicated in flat skin lesions that cannot be easily aspirated.

FALSE

Iron deficiency results in a macrocytic hypochromic anemia.

FALSE

Histiocytes are lymphocyte-derived macrophages and dendritic cells.

FALSE

monocyte-derived

Platelets vary in size in all species.

TRUE

At the site of vascular injury plasma fibronectin deposition occurs even before platelets adhere.

TRUE

Defective secondary hemostasis presents as hemorrhage from small blood vessels subjected to daily minor trauma.

FALSE

Excessive fibrinolysis is a consequence of disseminated intravascular coagulation (DIC) and attributed to excess thrombin generation.

FALSE

plasmin generation

Dysplasia is usually seen in mesenchymal tissue secondary to inflammation or irritation.

FALSE

Effusions are formed when the plasma exits from the vascular bed in the tissue and exits the interstitial space.

FALSE

Thrombin activates FX and cleaves fibrinogen to soluble fibrin which is crosslinked to insoluble fibrin by FXIIIa.

FALSE

New methylene blue is the stain used for counting reticulocytes.

TRUE

In the line smear technique, the spreader slide is lifted off the specimen slide prior to creating a feathered edge.

FALSE

The extrinsic pathway consists of tissue factor and FVIII, Calcium, TF-FVIla complex.

FALSE

Bone marrow aspiration sites commonly used for collection include the iliac crest, trochanter and humerus.

FALSE

femur

Packed cell volume is the parameter usually used to assess the basic status of red blood cells.

TRUE

Stain precipitate appears as fine, dark blue-purple stippled material on the background of the slide and on the cells.

TRUE

Platelet aggregation is mediated by glycoprotein IIIb in its activated form.

FALSE

GP IIb -IIIa

Thrombin generation is both the product of and regulator of coagulation activation.

TRUE

Features of anernia

Low TRBC, PCV and Hemoglobin

Stress leukogram

Neutrophilia, no left shift, lymphopenia, monocytosis, no toxic change

Erythrocytosis

Increased PCV, increased Hemoglobin conc, normal TRBC

Regenerative anemia

Anisocytosis, Increased nRBC, basophilic stippling, increased RBC with Howell-Jolly bodies

Primary hemostasis

Hemorrhage from mucosal surfaces

Mechanisms for changes in electrolyte concentration

Translocation, Excretion or loss, Intake of electrolytes

Baroreceptors

Aortic arch and carotid sinus

Hypenatremia

Water deficit, Salt gain, Hypertonic fluid administration

Hypochloremia

Vomiting, Displaced abomasum, gastric reflux in horses

Hyperkalemia

Shifting of potassium ions from ICF to ECF, Anuric or oliguric renal failure, Marked dehydration in ruminants