Depression

what is Dx Ciertia for depression

5 or more of the following symptoms for a period of at least 2 weeks (at least one must be depressed mood or anhedonia):

• Depression - Concentration/Energy

• Psychomotor agitation retardation(inc/dec in movement)

• Anhedonia -  excessive guilt/worthlessness -SI

Sleep Disturbance- Appetite changes-Intrest or enjoyment

Depression in children can present differently than adoldence and even in older adults. What are the differnerence between child-YA-older adults?

Children → inc anxeity

Adolescents → inc irrability

older adults → goes undetected often

What are the 3 age groups that have thhe highest sucide rates

• mid adolescence (3rd leading cause of death for this age group)

• middle age

• 75 years +

What Neurotransmitters are being affected in the neurobiology of depression? What are some examples of conditions that are assocated with neuroendocrine that can lead to depression.

-serotonin, dopamine, and norepinephrine.

-Hyperthoyidism and hypothyroidism

what the 3 NEWER drugs classes and what the main drugs and what side effects do they have?

Selective Serotonin Reuptake Inhibitors (SSRI's)

Generic	Trade	Side effects
Fluoxetine	Prozac	Gastrointestinal distress
Sertraline	Zoloft	Sedation
Citalopram	Celexa	Dizziness
Escitalopram	Lexapro (10-20mg)	Diaphoresis

Serotonin Norepinephrine Reuptake inhibitors (SNRI's)

Generic	Trade	Side effects
Duloxetine	Cymbalta	Anticholinergic effects aka dehydration
Venlafaxine	Effexor	Decreased appetite

Norepinephrine Dopamine Reuptake Inhibitor(NDRI)

Bupropion

Wellbutrin

Anticholinergic effects

What medication is used for ADHD and smoking cessation but NOT for ED

Bupropion (Wellbutrin)

What drug causes Priapism ?

Trazadone

Name one drugs from these classes?

Alpha 2 Antagonist

Monoamine Oxidase Inhibitors (MAOIs)

Trycyclic Antidepressant (TCA’s)

Alpha 2 Antagonist

• Mirtazapine

Monoamine Oxidase Inhibitors (MAOIs)

• Phenelzine (nardil)

Trycyclic Antidepressant (TCA’s)

• Amitrityline

What drug class do u not give for schizophernia and is leathally toxic at 1mg+?

TCA → Tricyclic Antidepressants

Serotonin syndrome

Define

Time frame

cause

S/sx

Define → excess serotonin

Time frame → hrs to days

cause → taking two or more medications that inc serotonin lvl

S/sx →  AMS(altered mental state), myoclonus, hyperreflexia, fever, diarrehea

Light therapy is used for what type of depressive disoder?

SAD (seasonal depression disorder)

Define these terms

1. Disruptive mood dysregulation Disorder (DMDD)

2. Major depressive disorder (MDD) ? s/sx

3. Persistent depressive disorder (dysthymia) ? s/sx

4. Premenstrual dysphoric

1. Disruptive mood dysregulation Disorder (DMDD)

• Severe irritability and outbursts of temper tantrums before age 10 usually results in a damage of property or persons 

2. Major depressive disorder (MDD) 5 s/sx

•  Most common

3. Persistent depressive disorder (dysthymia) 3 s/sx

• 2 years for an adult and 1 year for children and adolescents

4. Premenstrual dysphoric

• Recurring mood swings, feelings of sadness, or sensitivity to rejection in the final week before the onset of menses