Diuretics

diuretics are used to control _______, ________, ________, ______, or _______

blood pressure, removes excess fluid, treat edema, or fluid retention

thiazide diuretics act on the ________.

dist convoluted tubule

approximately __________% of sodium chloride is reabsorbed in the DCT.

5-10%

thiazide diuretics inhibit __________ reabsorption in the DCT, decreasing blood volume and BP.

NaCl

the __________ cotransporter moves NaCl from the tubule lumen into DCT cells.

NaCl (NCC)

the __________ pump moves 2 K+ into the cell and 3 Na+ out of the DCT cell.

Na+/K-ATPase

Na+ moves into DCT cells while __________ moves out through the Na+/Ca2+ exchanger (NCX).

Ca2+

parathyroid hormone controls _________ reabsorption form tubule lumen.

Ca2+

inhibition of NCC by thiazide diuretics leads to __________ and __________ remaining in the tubule.

Na+ and Cl--

examples of diuretics include _________ and _________.

hydrochlorothiazide, chlorothiazide

examples of thiazole-like diuretics include ________ and _________.

chlorthalidone and metolazone