Bursa of Fabricius

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10 Terms

1
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In which animal group can Bursa of Fabricius be found?

Avian (birds)

2
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<p>Describe the <span style="color: red"><strong>shape</strong></span><strong> </strong>and <span style="color: red"><strong>location</strong></span><strong> </strong>of the <span style="color: red"><strong>Bursa of Fabricius</strong></span></p>

Describe the shape and location of the Bursa of Fabricius

It’s a blind, sac-like structure on the caudodorsal side of the cloaca

  • Blind: Close ended pouch (doesn’t lead to another passage)

  • Caudal: Towards the tail end of bird

  • Dorsal: On upper/back side

3
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When does it reach its maximum size?

By 6 weeks

4
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What happens after it reaches its maximum size at 6 weeks?

It slowly involutes (regresses) until a small remnant is present in adult

5
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What is the main function of bursa of Fabricius?

Responsible for the production, maturation and differentiation of B-lymphocytes

<p>Responsible for the <span style="color: red"><strong>production</strong></span><strong>, </strong><span style="color: red"><strong>maturation</strong></span><strong> </strong>and <span style="color: red"><strong>differentiation</strong></span><strong> </strong>of <span style="color: red"><strong>B-lymphocytes </strong></span></p>
6
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What is the structure of Bursa of Fabricius?

Contains

  • Muscosal folds (plicae) that project into its lumen

  • With numerous lymphoid nodules (follicles)

  • In the lamina propria of each fold

7
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What are the 2 main regions of the lymphoid nodules in the Bursa of Fabricius?

  • Staining

  • Contains

  • Cortex:

    • Staining: Darker staining

    • Contains: Densely packed with small lymphocytes

  • Medulla:

    • Staining: Lighter staining

    • Contains:

      • Lymphocytes

      • Macrophages

      • Reticular epithelial cells

8
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What type of cells are found in the Bursa of Fabricius?

Lymphoid cells of the B-cell lineage

<p><span style="color: red"><strong>Lymphoid cells </strong></span>of the <span style="color: red"><strong>B-cell</strong></span><strong> </strong>lineage </p>
9
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What type of epithelium covers the surface of the Bursa folds?

Pseudostratified columnar epithelium

<p><span style="color: red"><strong>Pseudostratified columnar epithelium </strong></span></p>
10
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What staining technique is used to observe the structure of the Bursa?

Azure-Eosin staining