Enzyme Complexes and Metabolic Pathways

These flashcards cover key concepts related to enzyme complexes and metabolic pathways studied in the lecture.

Enzyme complex of the ETS that only initiates shuttling of protons across the membrane:

Succinate dehydrogenase

Pyruvate dehydrogenase donates covalently linked carbons 2 and 3 to form ______:

AcetylCoA

Dehydrogenases within the mitochondrial matrix will donate hydrides to 4 _____ for each pyruvate that becomes completely oxidized:

NAD+

The two NADHs produced by glycolytic enzyme GAPDH are exchanged to the mitochondrial inner membrane using the _____ shuttle to result in the production of 3 ATPs:

Glycerol-3-phosphate

The two NADHs produced by glycolytic enzyme GAPDH are exchanged to the mitochondrial matrix using the _____ shuttle to result in the production of 5 ATPs:

Malate-aspartate

Acetyl is linked to the Coenzyme A chain by a ______ bond:

Thioester

Electrons are conducted within the subunits of Complex II along a series of ______s to the ubiquinone reducing site:

Iron-sulfur cluster

The most potent reducing agent that induces the transfer of the highest number of protons from the matrix to the intermembrane space is _____:

NADH

26 of the 30 ATPs produced within skeletal muscle from a single glucose are made using ______:

Chemiosmosis

Complete oxidation of pyruvate produces 3 _____ molecules:

Carbon Dioxide

Enzyme complex that delivers protons to the intermembrane space side of the mitochondrial inner membrane AND reduces cytochrome c:

Cytochrome b-c1

The highly exergonic nature of the formation of citrate depends on the replacement of the thioester bond to CoA by the formation of a delocalized orbital ______ group:

Carboxyl

Enzyme complex of the ETS which both pumps and initiates shuttling of protons across the membrane:

NADH dehydrogenase

Succinate dehydrogenase contains a covalently linked ____ which becomes reduced by a hydride:

FAD

Enzyme complex that reduces O2 to produce two water molecules:

Cytochrome c oxidase

Oxidation of succinate results in the formation of a _____ bond in fumarate:

Double

One ____ per pyruvate is produced in a substrate-level phosphorylation within the Citric Acid Cycle:

ATP