MedChem Final (Biologic DMARDs)

Infliximab

Remicade

What is the target of Infliximab?

TNF-α 

What is the mechanism of Infliximab?

Blocks TNF-α  binding

Etanercept

Enbrel

What is the target of Etanercept?

TNF-α 

What is the mechanism of Etanercept?

Intercepts free TNF-α 

Adalimumab

Humira

What is the target of Adalimumab?

TNF-α 

What is the mechanism of Adalimumab?

blocks TNF-α 

Anakinra

Kineret

What is the target of Anakinra?

IL-1

What is the mechanism of Anakinra?

IL-1 receptor agonist

Rilonacept

Arcalyst

What is the target of Riloncept?

IL-1

What is the mechanism for Rilonacept?

Decoy receptor of IL-1alpha and IL-1beta

Canakinumab

Ilaris

What is the target of canakinumab?

IL-1β

What is the mechanism of canakinumab?

neutralizes IL-1β

Tocilizumab

Actemra

What is the target of Tocilizumab?

IL-6

What is the mechanism of tocilizumab?

Blocks IL-6 receptor

Secukinumab

Cosentyx

What is the target of secukinumab?

IL-17A or IL-17AR

What is the mechanism of secukinumab?

Neutralizes IL-17 pathway

Ixekizumab

Taltz

What is the target of ixekizumab?

IL-17A or IL-17AR

What is the mechanism of ixekizumab?

Neutralizes IL-17 pathway

Brodalumab

Siliq

What is the target of brodalumab?

IL-17A or IL-17AR

What is the mechanism of brodalumab?

Neutralizes the IL-17 pathway

Guselkumab

Tremfya

What is the target of guselkumab?

IL-23/IL-12

What is the mechanism of guselkumab?

Blocks the IL-23/12 pathway

Risankizumab

Skyrizi

What is the target of risankizumab?

IL-23/12

What is the mechanism of risankizumab?

Blocks the IL-23/12 pathway

Usetkinumab

Stelara

What is the target for usetkinumab?

IL-23/12

What is the mechanism for usetkinumab?

Blocks the IL-23/12 pathway

Abatacept

Orencia

What is the target of Abatacept?

CD80/86

What is the mechanism of abatacept?

CTLA4-Ig fusion blocks T-cell co-stimulation