BLG408 week 6: herpes viruses

how long does herpes last?

life long

what part of the body does HSV-1 usually infect?

mouth or pharynx

what part of the body does HSV-2 usually infect?

genitals

where is HSV-1 latent?

trigeminal nerve

where is HSV-2 latent?

sacral ganglia

what is a common symptom seen in HSV-1 infections?

mouth sores

what is HSV-2 associated with?

sexual transmission

what is HSV-1 associated with?

infections in children

what herpetic diseases can HSV-1 cause? (5)

1. cold sores

2. herpes heratitis

3. herpes gladiatorum

4. herpes rugbeiorum

5. genital herpes (10%)

herpes keratitis

infection of the eye and can cause corneal blindness

herpes gladiatorium is transmitted during

frequent contact in wrestling

where is herpes rubeiorum seen in?

contact sports (e.g., rugby)

HSV-2 causes ___% of genital herpes cases

90

pregnant women with which herpes virus should deliver via c-section?

HSV-2

what does varicella zoster virus (VSV) cause?

chickenpox and shingles

what is the only herpesvirus that spreads airborne

varicella zoster virus

when do symptoms develop after contact with a person with chickenpox?

10-21 days

what part of the body does VZV infect? (3 steps)

- skin or respiratory mucosa

- progresses through blood and lymphatic system

- to reticuloendothelial system

what is the first sign of chickenpox?

itchy exanthematous rash

what are the 3 complications that can occur if adults get chickenpox?

1. pneumonia

2. skin bacterial infection

3. encephalitis (swelling of the brain)

what vaccine is given to children for chickenpox?

varivax

why do individuals after a chickenpox develop shingles later on?

VZV remains latent and is reactivated later in life

where does VZV stay latent?

dorsal root ganglia

what occurs when VZV is reactivated later in life?

shingles (60year+)

what is the most definitive test for diagnosing herpesvirus infections?

presence of viable herpesvirus in clinical specimen

what membrane type do herpesviruses have?

enveloped

what type of genome do herpesviruses have?

linear dsDNA

what shape are herpesviruses?

icosahedral

what is the amorphous proteinaceous tegument?

surrounds nucleocapsid

what are the 5 steps of herpesvirus entry and fusion

1. gB/C attaches to proteoglycan

2.

what is the role of the virion host shutoff (vhs) tegument protein?

plays a role in mRNA degradation so viral mRNA can accumulate

what is the role of the VP16 tegument protein?

activator of transcription

what type of vaccine is used to prevent chickenpox?

live attenuated vaccine