Physiology Chapter 6 part 2: cell signalling

protein kinases

phosphorylate protiens to inactive/active

adenylyl cyclase converts ____ into ____

ATP, cAMP

cyclic AMP activates ____, which phosphorylates proteins to create a response

protein kinase A (PKA)

A ____ binds to activate a G protein receptor

ligand

Phospholipase C converts membrane phospholipids into ___ and ____

diacylglycerol and inositol triphospate

diacylglycerol activates _____, leading to _____

protein kinase C, phosphorylated protein and cellular response

Inositol triphosphate stimulates ____ leading to ____ 

Ca2+ release, cellular response

Inhibition of phospholipase A2 enzymes would directly reduce production of ____

arachidonic acid

the two products of arcachidonic acid are ____ and ____

lipoxygenase and cyclooxygenase

nonsteroidal anti-inflammatory medications like ibuprofen reduce pain and fever by inhibiting _____ and therefore reducing production of ________

cyclooxygenases, thromboxanes and prostaglandins

lipooxygenases produce _____ which induce inflammation such as asthma

leukotrienes

4 functions of calcium as a signaling molecule

enzyme activation (calmodulin), contraction, exocytosis, movement