Extracellular Matrix and Wound Healing

These flashcards cover key terms related to the extracellular matrix, its components, and the processes involved in wound healing.

Extracellular Matrix

A three-dimensional network of molecules that provide structure and biochemical support to surrounding cells.

Fibroblasts

Cells that generate the extracellular matrix and its components, including collagen and elastin.

Collagen

A fibrous protein that provides strength and structure to connective tissue.

Elastin

A protein that provides elasticity to the extracellular matrix, allowing tissues to stretch and return to their original shape.

Ground Substance

The liquid part of the extracellular matrix that holds components together, allowing for cell movement and interaction.

Glycoproteins

Proteins that have carbohydrate groups attached, involved in cell-cell interactions; examples include fibronectin and laminin.

Proteoglycans

Molecules made of a core protein and glycosaminoglycans (GAGs) that trap water and provide cushioning to tissues.

Glycosaminoglycans (GAGs)

Long, negatively charged polysaccharides involved in attracting water and providing structural support in connective tissues.

Hemostasis

The process that prevents and stops bleeding, marking the start of wound healing.

Angiogenesis

The formation of new blood vessels, crucial in the wound healing process.

Proliferation

The stage in wound healing where new tissue is formed to cover the wound.

Myofibroblast

A specialized fibroblast that contains contractile fibers and helps in pulling the wound edges together.

Fibronectin

A glycoprotein that aids in cell adhesion and is part of the extracellular matrix.

Integrins

Transmembrane proteins that facilitate communication between the extracellular matrix and the cell cytoskeleton.

Laminin

A glycoprotein that plays a key role in the basal lamina structure beneath epithelial cells.

Matrix Remodeling

The process of maturation and reorganization of the extracellular matrix after wound healing.

Cell Wall (Plants)

A rigid layer that surrounds plant cells, primarily composed of cellulose, providing structure and protection.